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Minnesota Twins vs Cleveland Guardians Prediction 4/29/25 MLB Picks

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Cleveland Guardians (15-13) vs Minnesota Twins (13-16)

Game Info: Tuesday, April 29, 2025 at 6:10 pm (Progressive Field)

The Line: Betting Odds: Cleveland Guardians -155 / Minnesota Twins +130 — Over/Under: 8

(Get latest betting odds)

The Minnesota Twins and Cleveland Guardians meet Tuesday in MLB action at Progressive Field. Here’s a Minnesota Twins vs Cleveland Guardians Prediction. This article will include a Minnesota Twins vs Cleveland Guardians Pick.

Minnesota Twins Betting Preview

The Minnesota Twins are 13-16 on the year and play the Red Sox, Orioles, and Giants next. The Minnesota Twins are batting .234 on the season, have a .310 OBP, and a .371 slugging percentage. The Minnesota Twins pitching staff has a 3.55 ERA and a 1.21 WHIP. Ty France leads the Minnesota Twins with 25 hits and 17 RBI, while Byron Buxton and Trevor Larnach have combined for 48 hits and 31 RBI. 

Chris Paddack gets the ball for the Minnesota Twins, and he is 0-3 with a 6.45 ERA and 20 strikeouts this season. This will be Paddack’s second career game against the Cleveland Guardians.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 15-13 on the year and play the Blue Jays, Nationals, and Phillies next. The Cleveland Guardians are batting .237 on the season, have a .306 OBP, and a .381 slugging percentage. The Cleveland Guardians’ pitching staff has a 4.61 ERA and a 1.46 WHIP. Steven Kwan leads the Cleveland Guardians with 38 hits and 15 RBI, while Jose Ramirez and Gabriel Arias have combined for 49 hits and 25 RBI.

Tanner Bibee gets the ball for the Cleveland Guardians, and he is 2-2 with a 5.19 ERA and 20 strikeouts this season. Bibee is 2-0 with a 2.72 ERA and 45 strikeouts in his career against the Minnesota Twins.

Why the Cleveland Guardians will win

Why the Minnesota Twins will win

Cleveland Guardians Player Prop Facts

Minnesota Twins Player Prop Facts

Minnesota Twins vs Cleveland Guardians Prediction

The Guardians are getting the benefit of the doubt because they’re at home with the better pitcher, but they’ve lost four of their last five games and have been shaky offensively. The Twins have quietly won six of their last seven games and are rolling with their lineup and pitching staff. Also, while Paddack has rough numbers on the season, it’s because of a bad season opener. Paddack has allowed seven earned runs in his last 19 innings while striking out 18. Paddack has allowed three or fewer earned runs in each of his last four starts. It’s only a matter of time before the Twins give him some run support. Give me the Twins and the plus money. 

Randy Chambers's Pick: Minnesota Twins +130

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