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Milwaukee Brewers vs Pittsburgh Pirates Prediction 9/16/2026 Today’s MLB Picks

Jul 9, 2026; St. Louis, Missouri, USA; Milwaukee Brewers starting pitcher Logan Henderson (43) throws against the St. Louis Cardinals during the fourth inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

Jul 9, 2026; St. Louis, Missouri, USA; Milwaukee Brewers starting pitcher Logan Henderson (43) throws against the St. Louis Cardinals during the fourth inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

MATCHUP Milwaukee Brewers Pittsburgh Pirates
Team Records 94-57 75-76
Spread -1.5 119 +1.5 -144
Moneyline -137 +114
Total Over 7.5 (-111) Under 7.5 (-109)
Where PNC Park, Pittsburgh, Pennsylvania
When Wednesday, September 16, 2026
Time 06:40 PM EDT
TV MLB.TV
In this article, we will formulate a Brewers vs Pirates Prediction for this MLB matchup on Wednesday, September 16th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Pittsburgh Pirates Preview


The Pittsburgh Pirates have a 75-76 record this season and are sitting in the 3rd place of the NL Central. They have a 38-35 home record and are coming off a 1-5 home loss against the Brewers. They will face the Royals and the Cardinals next.

The Pittsburgh Pirates have a .253 batting average this season, .330 OBP and .401 Slugging percentage. Pittsburgh’s pitching staff has a 4.18 ERA and 1.30 WHIP. Nick Gonzales is the team’s best hitter with a .307 batting average. Brandon Lowe leads the team in RBI with 86, adding a team-high 30 home runs.

Jared Jones (R) is the projected starting pitcher for the Pirates, and he has a 4-6 record, 4.10 ERA and 1.17 WHIP.

Milwaukee Brewers Preview


The Milwaukee Brewers have a 94-57 record this season and are sitting in the 1st place of the NL Central. They have a 42-31 away record and are coming off a 5-1 road win against the Pirates. They will face the Orioles and the Phillies next.

The Milwaukee Brewers have a .259 batting average this season, .342 OBP and .406 Slugging percentage. Milwaukee’s pitching staff has a 3.56 ERA and 1.19 WHIP. Jackson Chourio is the team’s best hitter with a .289 batting average. Brice Turang leads the team in RBI with 92, while Jake Bauers adds a team-high 26 home runs.

Logan Henderson (R) is the projected starting pitcher for the Brewers, and he has a 10-3 record, 2.34 ERA and 0.78 WHIP.

Milwaukee Brewers @ Pittsburgh Pirates Betting Trends: September 16, 2026


Why the Pittsburgh Pirates will win

Why the Milwaukee Brewers will win

Total Runs Facts

Pittsburgh Pirates Player Prop Facts

Milwaukee Brewers Player Prop Facts

Matchup/League Facts

Brewers vs Pirates Prediction


The Brewers have won their last four meetings against the Pirates but are 1-3 in their last four visits in Pittsburgh.

In this Brewers vs Pirates Prediction, the Brewers are coming as -135 road favorites. I like the Brewers in this one, as they have been red-hot lately with a 6-1 record in their last 7 games and have Logan Henderson on the mound, who has a 2.34 ERA and 0.78 WHIP this season and has been in excellent form. Jones has also been very good as of late, but the Pirates’ bats have been ice-cold lately and their bullpen has an almost 7 ERA in their last 5 games. Take the Brewers to win.

Nikos Lagouretos's Pick: Milwaukee Brewers ML

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