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Los Angeles Dodgers vs Chicago Cubs Prediction 4/23/25 MLB Picks

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Chicago Cubs (15-10) vs Los Angeles Dodgers (16-8)

Game Info: Wednesday, April 23, 2025 at 7:00 pm (Wrigley Field)

The Line: Betting Odds: Chicago Cubs -110 / Los Angeles Dodgers -110 — Over/Under: 8

(Get latest betting odds)

The Los Angeles Dodgers and the Chicago Cubs meet Wednesday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Dodgers vs. Chicago Cubs prediction.

Starting Pitching Matchup

The Los Angeles Dodgers did not have a starting pitcher announced at the time that this article was posted. The Chicago Cubs will send out Matthew Boyd for the start, and Boyd is 1-2 with a 2.01 ERA and 20 strikeouts this season. In his career, Boyd is 1-1 with a 3.00 ERA and 13 strikeouts against the Dodgers.

Los Angeles Dodgers Recap

The Los Angeles Dodgers come into this game looking to bounce back from an 11-10 loss to the Cubs in Tuesday’s matchup to fall to 16-8 on the year. After this series, the Dodgers will head home for a series with the Pittsburgh Pirates.

Dodgers Looking To Rebound

Shohei Ohtani leads the Dodgers with 23 hits, including 6 home runs, while Tommy Edman has 23 hits with a team-high 7 home runs and 15 RBIs. Michael Conforto has 13 hits with 4 doubles, while Teoscar Hernandez has 20 hits with 5 home runs, 4 doubles, and 17 RBIs as well this season. Ohtani has a team-high 5 stolen bases, while Max Muncy has 5 doubles but also has the team lead with 28 strikeouts so far this season. Mookie Betts has also chipped in 4 home runs and 10 RBIs on the year.

Why the Los Angeles Dodgers will win

Los Angeles Dodgers Player Prop Facts

Chicago Cubs Recap

The Chicago Cubs come into this game looking to add on to their win over the Dodgers from Tuesday’s matchup to improve to 15-10 on the year. After this series, the Cubs will square off against the Philadelphia Phillies at home.

Cubs Looking For Back-To-Back Series Wins

Kyle Tucker leads the Cubs with 29 hits, including team-highs of 8 doubles, 6 home runs, and 23 RBIs, while Seiya Suzuki also has 22 hits with a pair of doubles and 6 home runs and 18 RBIs of his own. Miguel Amaya added 6 doubles and 12 RBIs, and Pete Crow-Armstrong also has contributed 8 doubles this season. Dansby Swanson has added 4 home runs and 12 RBIs, while he also has the unfortunate distinction of leading the Cubs with 30 strikeouts so far this season. Crow-Armstrong also has a team-high 8 stolen bases, while Nico Hoerner has 6 stolen bases this season. Michael Busch has also chipped in 5 home runs and 16 RBIs this season.

Why the Chicago Cubs will win

Chicago Cubs Player Prop Facts

Total Runs Facts

Los Angeles Dodgers vs. Chicago Cubs Prediction

I’m on the over in this game. I just think this is going to be a higher-scoring game, as maybe the Dodgers have exorcised their demons against left-handed pitching after breaking out offensively on Tuesday, and I think the Cubs can do damage off of this Dodger bullpen if it’s a bullpen game or whoever the Dodgers send out for a spot start. Either way, I’m expecting runs, so give me the over.

Chris Ruffolo's Pick: Over 8

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