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Houston Astros vs St. Louis Cardinals Prediction 4/15/25 MLB Picks

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St. Louis Cardinals (8-8) vs Houston Astros (7-9)

Game Info: Tuesday, April 15, 2025 at 7:45 pm (Busch Stadium)

The Line: Betting Odds: St. Louis Cardinals +114 / Houston Astros -135 — Over/Under: 7.5

(Get latest betting odds)

The Houston Astros and the St. Louis Cardinals meet on Tuesday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Astros vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Houston Astros will send out Hunter Brown for the start here, and Brown is 1-1 with a 2.00 ERA and 18 strikeouts this season. This will be Brown’s first career start against the Cardinals. The St. Louis Cardinals will trot out Erick Fedde for the start here, and he is 1-1 with a 4.20 ERA and 5 strikeouts this season. This will be Fedde’s second career start against the Astros.

Houston Astros Recap

The Houston Astros come into this game looking to bounce back after starting the series with an 8-3 loss in Monday’s series opener to fall to 7-9 on the year. After this series, the Astros will head home for an interleague series against the San Diego Padres.

Astros Still Struggling To Be Consistent

Jose Altuve leads the Astros with 19 hits, including 3 home runs and 7 RBIs. Jeremy Pena also has a pair of homers and 4 stolen bases, while Yordan Alvarez has 2 doubles and a team-high 9 RBIs with 17 strikeouts as well. Brendan Rodgers has a pair of doubles, while Jake Meyers has a pair of doubles as well, and Christian Walker has also accrued a team-high 20 strikeouts so far this season. Altuve also has 3 stolen bases, while Jake Meyers has a team-high 5 stolen bases this season.

Why the Houston Astros will win

Houston Astros Player Prop Facts

St. Louis Cardinals Recap

The St. Louis Cardinals will try to keep the ball rolling after picking up the W in Monday’s series opener to get back to 8-8 on the year. After this series, the Cardinals will head on the road for a series against the New York Mets.

Cardinals Win Back-To-Back Games

Brendan Donovan has a team-high 21 hits, along with 4 doubles, 2 home runs, and 10 RBIs, while Lars Nootbaar has 15 hits with a pair of home runs and a pair of stolen bases. Noaln Arenado also has 15 hits with 4 doubles of his own, and Victor Scott II has 14 hits with a pair of doubles, a triple, 7 RBIs, and a team-high 5 stolen bases. Ivan Herrera has also added a team-high 4 home runs and 11 RBIs so far this season.

Why the St. Louis Cardinals will win

St. Louis Cardinals Player Prop Facts

Total Runs Facts

Houston Astros vs. St. Louis Cardinals Prediction

I’m on the under here. I think Erick Fedde’s lack of strikeouts will come back to bite him down the road, but not in this start with an Astros lineup that looks like a shell of what they’ve been in past seasons. On the other side, Hunter Brown is still one of Houston’s best arms and has staff ace stuff, and it wouldn’t surprise me if he ended up being Houston’s ace in a couple of years. I think he holds down the Cardinals lineup in a low-scoring battle here, so give me the under.

Chris Ruffolo's Pick: Under 7.5

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