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Houston Astros vs Seattle Mariners Prediction 9/23/2026 Today’s MLB Picks

Sep 16, 2026; Anaheim, California, USA;  Seattle Mariners starting pitcher George Kirby (68) delivers to the plate during the second inning against the Los Angeles Angels at Angel Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Sep 16, 2026; Anaheim, California, USA; Seattle Mariners starting pitcher George Kirby (68) delivers to the plate during the second inning against the Los Angeles Angels at Angel Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

MATCHUP Houston Astros Seattle Mariners
Team Records 78-79 73-84
Spread +1.5 -171 -1.5 141
Moneyline +123 -149
Total Over 8 (-105) Under 8 (-115)
Where T-Mobile Park, Seattle, Washington
When Wednesday, September 23, 2026
Time 10:00 PM EDT
TV ESPN
In this article, we will formulate a Astros vs Mariners Prediction for this MLB matchup on Wednesday, September 23rd in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview


The Seattle Mariners have a 73-84 record this season and are sitting in the 3rd place of the AL West. They have a 40-36 home record and are coming off a 0-7 home loss against the Astros. They will face the Angels next.

The Seattle Mariners have a .231 batting average this season, .312 OBP and .379 Slugging percentage. Seattle’s pitching staff has a 4.21 ERA and 1.26 WHIP. Randy Arozarena is the team’s best hitter with a .279 batting average, adding a team-high 76 RBI and a team-high 26 home runs.

George Kirby (R) is the projected starting pitcher for the Mariners, and he has a 9-11 record, 4.24 ERA and 1.39 WHIP.

Houston Astros Preview


The Houston Astros have a 78-79 record this season and are sitting in the 1st place of the AL West. They have a 39-37 away record and are coming off a 7-0 road win against the Mariners. They will face the Angels next.

The Houston Astros have a .240 batting average this season, .314 OBP and .411 Slugging percentage. Houston’s pitching staff has a 4.50 ERA and 1.34 WHIP. Yordan Alvarez is the team’s best hitter with a .314 batting average, leading the team in RBI with 102 and adding a team-high 41 home runs.

Ethan Pecko (R) is the projected starting pitcher for the Astros, and he has a 1-0 record, 3.77 ERA and 1.12 WHIP.

Houston Astros @ Seattle Mariners Betting Trends: September 23, 2026


Why the Seattle Mariners will win

Why the Houston Astros will win

Total Runs Facts

Seattle Mariners Player Prop Facts

Houston Astros Player Prop Facts

Matchup/League Facts

Astros vs Mariners Prediction


The Mariners are 7-3 in their last 10 meetings against the Astros and have won two of their last three meetings in Seattle.

In this Astros vs Mariners Prediction, the Mariners are coming as -145 home favorites. I like the Astros to keep rolling in this one after a shutout win yesterday. They are the only ones with something to play for, as the Mariners are on the verge of elimination. Kirby has been in bad form, having given up 3+ runs in five of his last seven starts, while Pecko has given up one run in each of his last three games played. The Mariners’ bats have been ice-cold, scoring just 2 runs per game against righties in their last 5, so I like the Astros as road dogs in this one. Get the Astros for plus money.

Nikos Lagouretos's Pick: Houston Astros ML

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