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Houston Astros vs Seattle Mariners Prediction 4/11/2026 Today’s MLB Picks

Apr 5, 2026; Anaheim, California, USA; Seattle Mariners pitcher Luis Castillo (58) throws against the Los Angeles Angels during the first inning at Angel Stadium. Mandatory Credit: Gary A. Vasquez-Imagn Images

Apr 5, 2026; Anaheim, California, USA; Seattle Mariners pitcher Luis Castillo (58) throws against the Los Angeles Angels during the first inning at Angel Stadium. Mandatory Credit: Gary A. Vasquez-Imagn Images

MATCHUP Houston Astros Seattle Mariners
Team Records 6-8 5-9
Spread +1.5 -175 -1.5 144
Moneyline +123 -149
Total Over 7.5 (-115) Under 7.5 (-105)
Where T-Mobile Park, Seattle, Washington
When Saturday, April 11, 2026
Time 09:40 PM EDT
TV ESPN Unlmtd

In this article, we will formulate an Astros vs Mariners Prediction for this MLB matchup on Saturday, April 11th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview

The Seattle Mariners have a 5-9 record this season and are sitting in the fifth place of the AL West. They have a 4-4 home record and are coming off a 9-6 home win against the Astros. Their previous three games were a 0-3, a 2-3, and a 1-2 road loss against the Rangers.

The Mariners have a .190 batting average this season, .297 OBP and .311 Slugging percentage. Seattle’s pitching staff has a 2.86 ERA and 0.98 WHIP. Brendan Donovan is the team’s best hitter with a .316 batting average. Cole Young leads the team in RBI with 8, and Luke Raley adds a team-high 3 home runs.

Luis Castillo (R) is the projected starting pitcher for the Mariners, and he has a 0-0 record, 2.79 ERA and 1.24 WHIP.

Houston Astros Preview

The Houston Astros have a 6-8 record this season and are sitting in the fourth place of the AL West. They have a 1-6 away record and are coming off a 6-9 road loss against the Mariners. Their previous three games were a 1-9, a 1-5, and a 7-9 road loss against the Rockies.

The Astros have a .270 batting average this season, .372 OBP and .449 Slugging percentage. Houston’s pitching staff has a 6.32 ERA and 1.68 WHIP. Yordan Alvarez is the team’s best hitter with a .341 batting average, also adding a team-high 5 home runs. Christian Walker leads the team in RBI with 13.

Lance McCullers Jr. (R) is the projected starting pitcher for the Astros, and he has a 1-0 record, 3.27 ERA and 1.18 WHIP.

Houston Astros @ Seattle Mariners Betting Trends: April 11, 2026

Why the Seattle Mariners will win

Why the Houston Astros will win

Total Runs Facts

Seattle Mariners Player Prop Facts

Houston Astros Player Prop Facts

Matchup/League Facts

Astros vs Mariners Prediction

The Mariners are 6-1 in their last 7 meetings against the Astros and are 3-1 in their last 4 meetings in Seattle.  

In this Astros vs Mariners Prediction, the Mariners are coming as -150 home favorites. The Astros have been struggling mightily with five consecutive wins and have at least 9 earned runs in four of their last five games. McCullers came back to earth after a quality start to the season while Castillo has been solid for the Mariners and both of his home starts against the Astros last season were shutouts. The Astros have the worst bullpen in baseball right now and the Mariners are better against right-handed pitching. Take the Mariners to win this one at home.

Nikos Lagouretos's Pick: Seattle Mariners ML

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