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Houston Astros vs Chicago Cubs Prediction 5/24/2026 Today’s MLB Picks

May 23, 2026; Chicago, Illinois, USA; Chicago Cubs shortstop Dansby Swanson (7) tags out Houston Astros center fielder Brice Matthews (0) at second base on a steal attempt during the ninth inning  at Wrigley Field. Mandatory Credit: David Banks-Imagn Images

May 23, 2026; Chicago, Illinois, USA; Chicago Cubs shortstop Dansby Swanson (7) tags out Houston Astros center fielder Brice Matthews (0) at second base on a steal attempt during the ninth inning at Wrigley Field. Mandatory Credit: David Banks-Imagn Images

MATCHUP Houston Astros Chicago Cubs
Team Records 22-31 29-23
Spread +1.5 -149 -1.5 124
Moneyline +147 -179
Total Over 7 (-122) Under 7 (101)
Where Wrigley Field, Chicago, Illinois
When Sunday, May 24, 2026
Time 02:20 PM EDT
TV MLB.TV
The Houston Astros and Chicago Cubs meet Sunday in MLB action at Wrigley Field. Here’s a Houston Astros vs. Chicago Cubs Prediction. This article will include a Houston Astros vs. Chicago Cubs Pick.

Houston Astros Betting Preview


The Houston Astros are 22-31 on the year and play the Rangers and Brewers next. The Houston Astros are batting. 246 on the season, have a .320 OBP, and have a .403 slugging percentage. The Houston Astros’ pitching staff has a 5.18 ERA and a 1.50 WHIP. Yordan Alvarez leads the Houston Astros with 57 hits and 31 RBI while Isaac Paredes and Christian Walker have combined for 93 hits and 54 RBI.

Peter Lambert gets the ball for the Houston Astros, and he is 2-4 with a 3.57 ERA and 35 strikeouts this season. Lambert is 2-0 with a 2.57 ERA and 14 strikeouts in his career against the Chicago Cubs.

Chicago Cubs Betting Preview


The Chicago Cubs are 29-23 on the year and play the Pirates and Cardinals next. The Chicago Cubs are batting .238 on the season and have a .335 OBP, and a .390 slugging percentage. The Chicago Cubs’ pitching staff has a 4.05 ERA and a 1.23 WHIP. Nico Hoerner leads the Chicago Cubs with 52 hits and 30 RBI, while Alex Bregman and Pete Crow-Armstrong have combined for 94 hits and 38 RBI.

Shota Imanaga gets the ball for the Chicago Cubs, and he is 4-4 with a 3.38 ERA and 61 strikeouts this season. This will be Imanaga’s first career game against the Houston Astros.

Why the Chicago Cubs will win

Why the Houston Astros will win

Total Runs Facts

Chicago Cubs Player Prop Facts

Houston Astros Player Prop Facts

Matchup/League Facts

Houston Astros vs Chicago Cubs Prediction


All of a sudden, the Astros have life and their pitching staff has really calmed down over their last four games. The Cubs are ice cold and they’ve scored 3 or fewer runs in 6 of their last 7 games. I’d still say the Cubs are the better team and Imanaga is fantastic when he’s right, but we’re getting nearly 1.5 times our money with a team that’s playing the better baseball. I have to side with the Astros and the more favorable price based on their current form.

Randy Chambers's Pick: Houston Astros

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