Guardians vs Nationals Prediction 5/7/25 MLB Picks

In this article, we will formulate a Guardians vs Nationals prediction for this MLB game on Wednesday, May 7th at Nationals Park in Washington, DC. Let’s take a look at the prediction for this MLB matchup. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 21-15 this year after they split the first two games in this series by scores of 9-10 and 9-1. In their game two win, Cleveland had their lead cut to 3-1 in the sixth inning, but they scored the last six runs to pull away with the win. The Guardians recorded eight hits in the game, and they were led by Santana, who went 1-4 with one home run and three RBIs in the win. Cleveland started Lively, who allowed two hits and one earned run over 5.1 innings in the win, while Herrin, Junis, and Kent combined for 3.2 scoreless innings in relief. 

Prior to this series, the Guardians won two out of three against the Blue Jays and three out of four against the Twins. Cleveland has won six of their last eight games, and they are currently second in the AL Central standings. The Cleveland pitching staff has a 4.26 ERA with a 1.41 WHIP and a .258 opponent batting average, while the offense has scored 149 runs with a .236 batting average and a .308 on-base percentage this season. Kyle Manzardo has led Cleveland with eight home runs and 21 RBIs, while Steven Kwan has added four home runs and 17 RBIs this year. The projected starting pitcher for Cleveland is Logan Allen, who is 1-2 with a 4.02 ERA and a 1.53 WHIP over 31.1 innings pitched this year. 

Washington Nationals Betting Preview

The Washington Nationals are 17-20 this season after they split the doubleheader on Tuesday. In their game two loss, the Nationals could only manage one run in the sixth inning, and they struggled with their pitching in the later innings for the blowout loss. The Nationals recorded four hits in the game, and they were led by Adams, who went 1-3 with one home run and one RBI in the loss. Washington started Lord, who allowed three hits and three earned runs over 6.0 innings in the loss, while Sims allowed one hit and three earned runs in just 0.1 relief innings. 

Prior to this series, the Nationals won two out of three against the Reds, but did lose two out of three against the Phillies before that. Washington has won three of their last four games, and they are currently fourth in the NL East standings. The Washington pitching staff has a 5.30 ERA with a 1.44 WHIP and a .264 opponent batting average, while the offense has scored 162 runs with a .239 batting average and a .309 on-base percentage this season. James Wood has led Washington with 10 home runs and 23 RBIs, while Nathaniel Lowe has added six home runs and 28 RBIs this year. The projected starting pitcher for Washington is Mitchell Parker, who is 3-2 with a 3.48 ERA and a 1.21 WHIP over 41.1 innings pitched this season.

Why the Guardians will beat the Nationals

• The Nationals have lost six of their last seven games at Nationals Park against AL Central opponents that held a winning record.
• The Guardians have won six of their last seven day games against National League opponents that held a losing record.
• The Nationals have failed to cover the run line in five of their last six games against American League opponents that held a winning record.
• The Guardians have covered the run line in four of their last five road games against National League opponents that held a losing record.
• The Guardians have led after 3 innings in three of their last four day games against National League opponents that held a losing record.

Total Runs Facts

• Each of the Guardians’ last four games have gone OVER the total runs line.
• Each of the Nationals’ last four home games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Guardians’ last five games as favorites against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Nationals’ last five games as underdogs against American League opponents.

Washington Nationals Player Prop Facts

• Nathaniel Lowe has recorded at least one RBI in six of the Nationals’ last eight games as underdogs.
• Josh Bell has scored at least one run in eight of his last 10 appearances in day games against teams that held a winning record.
• Keibert Ruiz has recorded a Single in each of his last eight appearances with the Nationals as underdogs against AL opponents.
• Keibert Ruiz has recorded at least one hit in each of his last eight appearances with the Nationals as underdogs against AL opponents.
• Paul DeJong has hit a home run in three of his last five appearances with his team as an underdog against the Guardians.

Cleveland Guardians Player Prop Facts

• Steven Kwan has recorded at least one hit in each of his last 13 appearances against NL East opponents.
• Steven Kwan has recorded at least one Single in each of his last 11 appearances against NL East opponents.
• Austin Hedges has hit a home run in three of his last four road appearances against opponents that held a losing record.
• Nolan Jones has recorded a Double in four of his last five appearances in day games against NL teams that held a losing record.
• Steven Kwan has scored at least one run in each of his last six road appearances against NL East opponents that held a losing record.
• Will Brennan has recorded an RBI in each of his three previous appearances against the Nationals at Nationals Park.

Guardians vs Nationals Prediction 

These two teams split the doubleheader on Tuesday, and they will be looking to get the series win in this contest. Washington is 10-8 at home this year, while Cleveland is 10-10 on the road. The Guardians have played very well over the last 10 days, and they will start Allen, who has allowed two earned runs or fewer in four of his last five starts. Washington is going with Parker, who has allowed 11 earned runs in his last two outings (9.0 IP). Take the Guardians to get the afternoon win here. 

David Racey's Pick: Guardians ML