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Colorado Rockies vs Houston Astros Prediction 4/16/2026 Today’s MLB Picks

Apr 1, 2026; Houston, Texas, USA; Houston Astros designated hitter Yordan Alvarez (44) hits a double against the Boston Red Sox during the first inning at Daikin Park. Mandatory Credit: Erik Williams-Imagn Images

Apr 1, 2026; Houston, Texas, USA; Houston Astros designated hitter Yordan Alvarez (44) hits a double against the Boston Red Sox during the first inning at Daikin Park. Mandatory Credit: Erik Williams-Imagn Images

MATCHUP Colorado Rockies Houston Astros
Team Records 6-12 8-11
Where Daikin Park, Houston, Texas
When Thursday, April 16, 2026
Time 08:10 PM EDT
TV MLB.TV

The Colorado Rockies and the Houston Astros meet Thursday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Colorado Rockies vs. Houston Astros prediction.

Starting Pitching Matchup

The Colorado Rockies will send out Juan Mejia for the start here and Mejia is 0-2 with a 5.40 ERA and 5 strikeouts this season. This will be Mejia’s first career start against the Astros. Ryan Weiss will start this one for the Astros and is 0-2 with a 7.36 ERA and 15 strikeouts this season. This will be Weiss’ first career start against the Rockies.

Colorado Rockies Recap

The Colorado Rockies come into this game looking to bounce back from a 3-1 loss at the hands of Houston last time out to sit at 6-12 this season. After this series, the Rockies will head home for a series against the Los Angeles Dodgers.

Rockies Drop 6th Straight

Entering Wednesday, TJ Rumfield has 17 hits with a double, a triple, 2 home runs and 8 RBIs while Ezequiel Tovar has 17 hits with 7 doubles, a home run and 6 RBIs. Hunter Goodman’s added 15 hits with a double, 4 home runs and 7 RBIs and Jordan Beck has 6 RBIs as well on the year. Troy Johnston has 14 hits with 3 doubles, 2 home runs and 7 RBIs. Willi Castro also has 11 hits with 3 doubles, a home run and 7 RBIs.

Houston Astros Recap

The Houston Astros come into this game fresh off of their win over the Rockies ton Wednesday improve to 8-11 on the year. After this series, the Astros will take on the St. Louis Cardinals at home.

Astros Win Back-To-Back Games

Going into Wednesday’s matchup, Yordan Alvarez has 19 hits with 5 doubles, 6 home runs and 16 RBIs while Christian Walker has 20 hits with 6 doubles, 4 home runs and 15 RBIs on the year. Jose Altuve’s chipped in 19 hits with 5 doubles, 2 home runs and 6 RBIs and Carlos Correa has 17 hits with 3 doubles, a home run and 9 RBIs. Cam Smith also has 18 hits with 4 doubles, 3 home runs and 9 RBIs. Yainer Diaz also has 11 hits with a double, a home run and 9 RBIs.

Colorado Rockies @ Houston Astros Betting Trends: April 16, 2026

Why the Houston Astros will win

Why the Colorado Rockies will win

Total Runs Facts

Houston Astros Player Prop Facts

Colorado Rockies Player Prop Facts

Matchup/League Facts

Colorado Rockies vs. Houston Astros Prediction

I’m on the Astros here. I get the case to be made for either side in this game, but the thing is that until the Rockies show that they can win a game on the road, it’s fade them in that spot at all costs. The Astros have used this series to get some confidence, just like the Mariners did against them the series prior and I think Houston completes the sweep here. Give me Houston.

Chris Ruffolo's Pick: Houston -185

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