Cleveland Guardians vs St. Louis Cardinals Prediction 4/14/2026 Today’s MLB Picks
Chris Ruffolo
Apr 12, 2026; St. Louis, Missouri, USA; St. Louis Cardinals right fielder Jordan Walker (18) hits a solo home run against the Boston Red Sox during the second inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images
MATCHUP
Cleveland Guardians
St. Louis Cardinals
Team Records
10-7
8-8
Where
Busch Stadium, St. Louis, Missouri
When
Tuesday, April 14, 2026
Time
07:45 PM EDT
TV
MLB.TV
The Cleveland Guardians and the St. Louis Cardinals meet Tuesday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs. St. Louis Cardinals prediction.
Starting Pitching Matchup
The Cleveland Guardians will send Joey Cantillo for the start here and Cantillo is 1-0 with a 2.45 ERA and 20 strikeouts this season. This will be Cantillo’s first career start against the Cardinals. Michael McGreevy will start for St. Louis here and is 1-1 with a 2.16 ERA and 10 strikeouts this season.
Cleveland Guardians Recap
The Cleveland Guardians come into this game looking to add on to their 9-3 win over St. Louis from Monday’s series opener to sit at 10-7 this season. After this series, the Guardians will head home for a series against the Baltimore Orioles.
Guardians Alternate Wins & Losses In 5 Straight
Entering Monday, Chase DeLauter has 15 hits with 4 doubles, a team-high 5 home runs and 12 RBIs while Steven Kwan has a 14 hits with 2 doubles, a home run and 4 RBIs and Jose Ramirez has 11 hits with 3 doubles, 2 home runs and 7 RBIs this season. Brayan Rocchio has also added 8 hits with a double, a home run and 6 RBIs this season while Angel Martinez has 13 hits with 3 doubles, a homer and 6 RBIs and Rhys Hoskins has added 9 hits with 5 doubles, a home run and 5 RBIs.
St. Louis Cardinals Recap
The St. Louis Cardinals come into this game looking to bounce back from their loss in Monday’s series opener to drop to 8-8 this season. After this series, the Cardinals will head on the road for a series against the Houston Astros.
Cardinals Lose Three Straight Games
Going into Monday’s opener, Jordan Walker leads the Cardinals with 18 hits, 2 doubles, 7 home runs and 14 RBIs while Alec Burleson has 14 hits with a pair of doubles, a pair of home runs and 11 RBIs. JJ Wetherholt has 12 hits with a home run and 5 RBIs while Ivan Herrera has 10 hits with 3 doubles and 6 RBIs. Nolan Gorman has 9 hits with 2 home runs and 9 RBIs this season.
Cleveland Guardians @ St. Louis Cardinals Betting Trends: April 14, 2026
Probable Starting Pitcher: Michael McGreevy Record this season: 1-1 ERA: 2.16
Home Record: 0-0
Last 5 against Guardians: –
Why the St. Louis Cardinals will win
The Guardians have lost each of their last five games as road favorites against NL Central opponents following a win.
The Cardinals have won six of their last eight games as underdogs against AL Central opponents following a loss.
The Guardians have failed to cover the run line in each of their last six road games following a win.
The Cardinals have covered the run line in each of their last six Tuesday games as home underdogs.
The Cardinals have led after 5 innings in three of their last four night games against AL Central opponents.
The Cardinals have led after 3 innings in three of their last four games against the Guardians.
Probable Starting Pitcher: Joey Cantillo Record this season: 1-0 ERA: 2.45
Road Record: 0-0
Last 5 against Cardinals: –
Why the Cleveland Guardians will win
The Cardinals have lost each of their last eight home games against American League opponents that held a winning record.
The road team has won each of the last four games between the Guardians and Cardinals.
The Cardinals have failed to cover the run line each of their last six games against American League opponents that held a winning record.
The Guardians have covered the run line in each of their last six games against NL Central opponents.
The Guardians have won the first inning in each of their last five Tuesday night games as favorites.
The Guardians have led after 3 innings in each of their last five Tuesday night games as favorites.
The Cardinals have trailed after 5 innings in each of their last six home games against AL Central opponents.
Total Runs Facts
Seven of the Cardinals’ last eight games as underdogs against the Guardians have gone OVER the total runs line.
Four of the Guardians’ last five games have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last six games as home underdogs against AL Central opponents.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Guardians’ last nine road games against NL Central opponents.
St. Louis Cardinals Player Prop Facts
Alec Burleson has hit a home run in four of his last 12 appearances against AL Central opponents.
Lars Nootbaar has recorded at least one hit in each of his last seven appearances in night games against teams that held a winning record.
Jordan Walker ranks 1st in the league in Home Runs (8) this season.
Cleveland Guardians Player Prop Facts
Brayan Rocchio has hit a home run in four of the Guardians’ last six games as favorites.
Steven Kwan has recorded two hits in each of the Guardians’ last four games as favorites against NL opponents.
Jose Ramirez ranks T2nd in the league in Steals (7) this season.
Matchup/League Facts
The Cardinals rank 30th in the league for strikeouts this season (97).
The Cardinals rank 29th in the league for opponent batting average this season (.268).
The Guardians rank 2nd in the league for strikeouts this season (166).
The Guardians rank T4th in the league for doubles this season (32).
Cleveland Guardians vs. St. Louis Cardinals Prediction
I’m on the Guardians here. I just think that Cantillo is the better starting option in this game and if anything I think the prime time for St. Louis to get the win was on Monday but here, I think the Guardians keep their foot on the gas against McGreevy, who for me is one of the weakest starters in the Cardinals’ rotation. Give me Cleveland.
