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Cleveland Guardians vs San Diego Padres Prediction 4/1/25 MLB Picks

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San Diego Padres (5-0) vs Cleveland Guardians (2-2)

Game Info: Tuesday, April 1, 2025 at 9:40 pm (Petco Park)

The Line: Betting Odds: San Diego Padres -166 / Cleveland Guardians +140 — Over/Under: 7.5

(Get latest betting odds)

The Cleveland Guardians and San Diego Padres meet on Tuesday in MLB action at Petco Park. Here’s a Cleveland Guardians vs San Diego Padres Prediction. This article will include a Cleveland Guardians vs San Diego Padres Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 2-2 on the year and play the Angels, White Sox, and Royals next. The Cleveland Guardians are batting .258 in the season and have a .325 OBP and a .485 slugging percentage. The Cleveland Guardians’ pitching staff has a 3.86 ERA and a 1.31 WHIP. Steven Kwan leads the Cleveland Guardians with 6 hits and 3 RBI, while Kyle Manzardo and Carlos Santana have combined for 9 hits and 7 RBI. 

Logan Allen gets the ball for the Cleveland Guardians, and he was 8-5 with a 5.73 ERA and 79 strikeouts last season. This will be Allen’s second career game against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 5-0 on the year and play the Cubs, Athletics, and Rockies next. The San Diego Padres are batting .290 on the season, have a .358 OBP, and a .426 slugging percentage. The San Diego Padres’ pitching staff has a 1.80 ERA and a 0.96 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 9 hits and 3 RBI, while Gavin Sheets and Jackson Merrill have combined for 14 hits and 10 RBI.

Michael King gets the ball for the San Diego Padres, and he is 0-0 with a 10.13 ERA and 3 strikeouts this season. King is 1-0 with a 0.51 ERA and 24 strikeouts in his career against the Cleveland Guardians.

Why the San Diego Padres will win

Why the Cleveland Guardians will win

Cleveland Guardians vs San Diego Padres Prediction

The Cleveland Guardians haven’t been able to catch a break through four games, and Allen is coming off a rough season, to say the least. Allen has a 4.65 ERA and 1.48 WHIP through 222.2 career innings. The Padres are rolling through five games and they’re getting it done from the plate and the mound. The one time the Padres’ starter didn’t perform was King, and he’s better than what he showed his first time out. The Padres are in too good of form at the moment to step in front of, especially when King has gotten the jitters out and should be better this time out. I’m rolling with the Padres and will lay the RL to shave down the juice.

Randy Chambers's Pick: San Diego Padres -1.5

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