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Cleveland Guardians vs Detroit Tigers Prediction 5/22/25 MLB Picks

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Detroit Tigers (33-17) vs Cleveland Guardians (26-22)

Game Info: Thursday, May 22, 2025 at 6:40 pm (Comerica Park)

The Line: Betting Odds: Detroit Tigers -135 / Cleveland Guardians +114 — Over/Under: 8

(Get latest betting odds)

The Cleveland Guardians and Detroit Tigers meet Thursday in MLB action at Comerica Park. Here’s a Cleveland Guardians vs Detroit Tigers Prediction. This article will include a Cleveland Guardians vs Detroit Tigers Pick.

Cleveland Guardians Betting Preview

The Cleveland Guardians are 26-22 on the year and play the Dodgers, Angels, and Yankees next. The Cleveland Guardians are batting .234 on the season, have a .307 OBP, and a .382 slugging percentage. The Cleveland Guardians’ pitching staff has a 4.12 ERA and a 1.41 WHIP. Steven Kwan leads the Cleveland Guardians with 60 hits and 17 RBI, while Jose Ramirez and Carlos Santana have combined for 89 hits and 48 RBI. 

Tanner Bibee gets the ball for the Cleveland Guardians, and he is 3-4 with a 4.06 ERA and 35 strikeouts this season. Bibee is 1-3 with a 5.28 ERA and 27 strikeouts in his career against the Detroit Tigers.

Detroit Tigers Betting Preview

The Detroit Tigers are 33-17 on the year and play the Giants, Royals, and White Sox next. The Detroit Tigers are batting .259 on the season, have a .331 OBP, and a .421 slugging percentage. The Detroit Tigers’ pitching staff has a 3.32 ERA and a 1.17 WHIP. Riley Greene leads the Detroit Tigers with 54 hits and 34 RBI, while Kerry Carpenter and Zach McKinstry have combined for 91 hits and 39 RBI.

Jack Flaherty gets the ball for the Detroit Tigers, and he is 2-5 with a 4.44 ERA and 56 strikeouts this season. Flaherty is 2-2 with a 1.96 ERA and 36 strikeouts in his career against the Cleveland Guardians.

Why the Detroit Tigers will win

Why the Cleveland Guardians will win

Detroit Tigers Player Prop Facts

Cleveland Guardians Player Prop Facts

Cleveland Guardians vs Detroit Tigers Prediction

These are two capable offenses and two pitchers who have struggled to find their form, so I’m going with the over in this spot. Bibee has a 4.06 ERA and 1.29 WHIP on the season, and through 26.1 road innings, he has a 6.49 ERA and .292 allowed batting average. Flaherty has allowed 17 hits and 11 earned runs in his last 14.1 innings. The Tigers have lost six of the last seven games Flaherty has pitched. I expect a high score on Thursday night. Give me the over.

Randy Chambers's Pick: Over 8

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