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Cleveland Guardians vs Chicago White Sox Prediction 6/23/2026 Today’s MLB Picks

Jun 22, 2026; Chicago, Illinois, USA; Chicago White Sox third baseman Colson Montgomery (12) and second baseman Chase Meidroth (10) attempt to dunk left fielder Sam Antonacci (17) after defeating the Cleveland Guardians at Rate Field. Mandatory Credit: Patrick Gorski-Imagn Images

Jun 22, 2026; Chicago, Illinois, USA; Chicago White Sox third baseman Colson Montgomery (12) and second baseman Chase Meidroth (10) attempt to dunk left fielder Sam Antonacci (17) after defeating the Cleveland Guardians at Rate Field. Mandatory Credit: Patrick Gorski-Imagn Images

MATCHUP Cleveland Guardians Chicago White Sox
Team Records 41-38 40-37
Spread -1.5 153 +1.5 -186
Moneyline -114 -105
Total Over 7 (-115) Under 7 (-104)
Where Rate Field, Chicago, Illinois
When Tuesday, June 23, 2026
Time 07:40 PM EDT
TV MLB.TV
The Cleveland Guardians and Chicago White Sox meet Tuesday in MLB action at Rate Field. Here’s a Cleveland Guardians vs Chicago White Sox Prediction. This article will include a Cleveland Guardians vs Chicago White Sox Pick.

Cleveland Guardians Betting Preview


The Cleveland Guardians are 41-38 on the year and play the Mariners and Rangers next. The Cleveland Guardians are batting. 228 on the season, have a .313 OBP, and have a .369 slugging percentage. The Cleveland Guardians’ pitching staff has a 3.82 ERA and a 1.26 WHIP. Brayan Rocchio leads the Cleveland Guardians with 69 hits and 33 RBI, while Chase DeLauter and Jose Ramirez have combined for 127 hits and 67 RBI.

Parker Messick gets the ball for the Cleveland Guardians, and he is 7-3 with a 2.70 ERA and 91 strikeouts this season. This will be Messick’s second career game against the Chicago White Sox.

Chicago White Sox Betting Preview


The Chicago White Sox are 40-37 on the year and play the Orioles and Royals next. The Chicago White Sox are batting .238 on the season, have a .319 OBP, and have a .410 slugging percentage. The Chicago White Sox pitching staff has a 4.42 ERA and a 1.34 WHIP. Chase Meidroth leads the Chicago White Sox with 76 hits and 25 RBI, while Colson Montgomery and Miguel Vargas have combined for 124 hits and 89 RBI.

Sean Burke gets the ball for the Chicago White Sox, and he is 4-4 with a 3.89 ERA and 81 strikeouts this season. Burke is 0-2 with a 4.40 ERA and 19 strikeouts in his career against the Cleveland Guardians.

Why the Chicago White Sox will win

Why the Cleveland Guardians will win

Total Runs Facts

Chicago White Sox Player Prop Facts

Cleveland Guardians Player Prop Facts

Matchup/League Facts

Cleveland Guardians vs Chicago White Sox Prediction


As I’ve said last night and I’ve said many times this season, the White Sox keep getting disrespected by oddsmakers. It’s like nobody believes in the White Sox, but we’re deep into the season to admit this is actually a decent to good team. You can make money betting on the White Sox. Messick has been solid through 86.2 innings, but who cares? I’m backing a team that’s made me money all season and keeps getting these favorable prices. Give me the White Sox.

Randy Chambers's Pick: Chicago White Sox

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