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Cleveland Guardians vs Baltimore Orioles Prediction 9/7/2026 Today’s MLB Picks

Sep 6, 2026; Cleveland, Ohio, USA; Cleveland Guardians shortstop Brayan Rocchio (4) celebrates with first baseman Nathaniel Lowe (46) after center fielder Daniel Schneemann (not pictured) hit a game-wining RBI single during the tenth inning against the Detroit Tigers at Progressive Field. Mandatory Credit: Ken Blaze-Imagn Images

Sep 6, 2026; Cleveland, Ohio, USA; Cleveland Guardians shortstop Brayan Rocchio (4) celebrates with first baseman Nathaniel Lowe (46) after center fielder Daniel Schneemann (not pictured) hit a game-wining RBI single during the tenth inning against the Detroit Tigers at Progressive Field. Mandatory Credit: Ken Blaze-Imagn Images

MATCHUP Cleveland Guardians Baltimore Orioles
Team Records 73-71 69-75
Spread +1.5 -199 -1.5 163
Moneyline +109 -131
Total Over 8.5 (-102) Under 8.5 (-118)
Where Oriole Park at Camden Yards, Baltimore, Maryland
When Monday, September 7, 2026
Time 01:35 PM EDT
TV MLB.TV
The Cleveland Guardians and Baltimore Orioles meet Monday in MLB action at Oriole Park. Here’s a Cleveland Guardians vs Baltimore Orioles Prediction. This article will include a Cleveland Guardians vs Baltimore Orioles Pick.

Cleveland Guardians Betting Preview


The Cleveland Guardians are 73-71 on the year and play the White Sox and Twins next. The Cleveland Guardians are batting .236 on the season, have a .313 OBP, and a .371 slugging percentage. The Cleveland Guardians pitching staff has a 3.75 ERA and a 1.26 WHIP. Chase DeLauter leads the Cleveland Guardians with 131 hits and 60 RBI, while Steven Kwan and Brayan Rocchio have combined for 247 hits and 87 RBI.

Joey Cantillo gets the ball for the Cleveland Guardians, and he is 9-8 with a 3.81 ERA and 151 strikeouts this season. Cantillo is 1-1 with a 4.91 ERA and 17 strikeouts in his career against the Baltimore Orioles.

Baltimore Orioles Betting Preview


The Baltimore Orioles are 69-75 on the year and play the Blue Jays and Mets next. The Baltimore Orioles are batting .234 on the season, with a .315 OBP and a .393 slugging percentage. The Baltimore Orioles pitching staff has a 4.13 ERA and a 1.34 WHIP. Pete Alonso leads the Baltimore Orioles with 144 hits and 94 RBI, while Leody Taveras and Gunnar Henderson have combined for 210 hits and 109 RBI.

Trevor Rogers gets the ball for the Baltimore Orioles, and he is 9-9 with a 4.30 ERA and 132 strikeouts this season. Rogers is 0-2 with a 6.91 ERA and 13 strikeouts in his career against the Cleveland Guardians.

Why the Baltimore Orioles will win

Why the Cleveland Guardians will win

Total Runs Facts

Baltimore Orioles Player Prop Facts

Cleveland Guardians Player Prop Facts

Matchup/League Facts

Cleveland Guardians vs Baltimore Orioles Prediction


The Orioles are coming off a horrible week that has put them on the back burner in terms of the playoff race. The Guardians are in far better shape and playing the better ball overall. Cantillo has also been stronger than Rogers with a 3.81 ERA and 1.48 WHIP through 141.2 innings. The fact that you can get the Guardians in this spot at a plus-money price feels too good to be true. Who is laying juice on the O’s in their current form? Not I. Give me the Guardians.

Randy Chambers's Pick: Cleveland Guardians

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