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Cincinnati Reds vs St. Louis Cardinals Prediction 7/25/2026 Today’s MLB Picks

Jun 27, 2026; St. Louis, Missouri, USA; St. Louis Cardinals starting pitcher Andre Pallante (53) throws against the Miami Marlins during the first inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

Jun 27, 2026; St. Louis, Missouri, USA; St. Louis Cardinals starting pitcher Andre Pallante (53) throws against the Miami Marlins during the first inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

MATCHUP Cincinnati Reds St. Louis Cardinals
Team Records 48-54 52-51
Spread -1.5 166 +1.5 -203
Moneyline -101 -120
Total Over 8.5 (-102) Under 8.5 (-118)
Where Busch Stadium, St. Louis, Missouri
When Saturday, July 25, 2026
Time 07:15 PM EDT
TV MLB.TV
In this article, we will formulate a Reds vs Cardinals Prediction for this MLB matchup on Saturday, July 25th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

St. Louis Cardinals Preview


The St. Louis Cardinals have a 52-51 record this season and are sitting in the 4th place of the NL Central. They have a 26-28 home record and are coming off a 2-4 home loss against the Reds. They will face the Cubs and the Blue Jays next.

The St. Louis Cardinals have a .240 batting average this season, .316 OBP and .382 Slugging percentage. St. Louis’s pitching staff has a 4.17 ERA and 1.34 WHIP. Jordan Walker is the team’s best hitter with a .288 batting average, leads the team in RBI with 77, and adds a team-high 22 home runs.

Andre Pallante (R) is the projected starting pitcher for the St. Louis Cardinals, and he has a 10-6 record, 4.02 ERA and 1.26 WHIP.

Cincinnati Reds Preview


The Cincinnati Reds have a 48-54 record this season and are sitting in the 5th place of the NL Central. They have a 26-26 away record and are coming off a 4-2 road win against the Cardinals. They will face the Guardians and the Pirates next.

The Cincinnati Reds have a .230 batting average this season, .309 OBP and .400 Slugging percentage. Cincinnati’s pitching staff has a 4.53 ERA and 1.43 WHIP. Elly De La Cruz is the team’s best hitter with a .276 batting average. Sal Stewart leads the team in RBI with 75, adding a team-high 21 home runs.

Hunter Greene (R) is the projected starting pitcher for the Cincinnati Reds, and he has a 2-1 record, 6.06 ERA and 1.16 WHIP.

Cincinnati Reds @ St. Louis Cardinals Betting Trends: July 25, 2026


Why the St. Louis Cardinals will win

Why the Cincinnati Reds will win

Total Runs Facts

St. Louis Cardinals Player Prop Facts

Cincinnati Reds Player Prop Facts

Matchup/League Facts

Reds vs Cardinals Prediction


The Cardinals are 3-1 in their last 4 meetings against the Reds and are 3-1 in their last 4 meetings in Cincinnati.    

In this Reds vs Cardinals Prediction, the Cardinals are coming as -120 home favorites. I don’t like the pitching in this matchup, as both pitchers have a combined 10.08 ERA and Pallante has been in poor form with a 5.71 ERA across his last three starts and much weaker at home with a 4.99 ERA. Both bullpens have been the third and fourth-worse in baseball after the break, so I’m expecting runs in this game. Take the over 8 in this one.

Nikos Lagouretos's Pick: Over 8

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