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Cincinnati Reds vs Cleveland Guardians Prediction 5/17/2026 Today’s MLB Picks

Apr 1, 2026; Los Angeles, California, USA;  Cleveland Guardians pitcher Gavin Williams (32) gets set on the mound in the seventh inning against the Los Angeles Dodgers at Dodger Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Apr 1, 2026; Los Angeles, California, USA; Cleveland Guardians pitcher Gavin Williams (32) gets set on the mound in the seventh inning against the Los Angeles Dodgers at Dodger Stadium. Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

MATCHUP Cincinnati Reds Cleveland Guardians
Team Records 24-23 26-22
Spread +1.5 -156 -1.5 129
Moneyline +133 -161
Total Over 8.5 (-117) Under 8.5 (-103)
Where Progressive Field, Cleveland, Ohio
When Sunday, May 17, 2026
Time 01:40 PM EDT
TV MLB.TV

In this article, we will formulate a Reds vs Guardians Prediction for this MLB matchup on Sunday, May 17th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Cleveland Guardians Preview

The Cleveland Guardians have a 25-22 record this season and are sitting in the first place of the AL Central. They have a 14-10 home record and are coming off a 7-4 home win against the Reds. They will face the Tigers and the Phillies next.

The Guardians have a .229 batting average this season, .323 OBP and .366 Slugging percentage. Cleveland’s pitching staff has a 3.88 ERA and 1.28 WHIP. Chase DeLauter is the team’s best hitter with a .278 batting average, also leading the team in RBI with 26. Angel Martinez adds a team‑high 8 home runs.

Gavin Williams (R) is the projected starting pitcher for the Guardians, and he has a 5-3 record, 3.74 ERA and 1.17 WHIP.

Cincinnati Reds Preview

The Cincinnati Reds have a 24-22 record this season and are sitting in the fifth place of the NL Central. They have a 11-11 away record and are coming off a 4-7 loss on the road against the Guardians. They will face the Phillies and the Cardinals next.

The Reds have a .226 batting average this season, .311 OBP and .392 Slugging percentage. Cincinnati’s pitching staff has a 4.64 ERA and 1.47 WHIP. Elly De La Cruz is the team’s best hitter with a .299 batting average, also leading the team in RBI with 30 and adding a team‑high 10 home runs.

Brady Singer (R) is the projected starting pitcher for the Reds, and he has a 2-3 record, 5.79 ERA and 1.67 WHIP.

Cincinnati Reds @ Cleveland Guardians Betting Trends: May 17, 2026

Why the Cleveland Guardians will win

Why the Cincinnati Reds will win

Total Runs Facts

Cleveland Guardians Player Prop Facts

Cincinnati Reds Player Prop Facts

Matchup/League Facts

Reds vs Guardians Prediction

The Reds are 6-2 in their last 8 meetings against the Guardians but are 3-4 in their last 7 meetings in Cleveland.

In this Reds vs Guardians Prediction, the Guardians are coming as -170 home favorites. Both pitchers in this matchup have been in bad form lately, but Gavin Williams has been solid at home for the Guardians with a 2.39 home ERA, while on the other hand, Singer has been terrible on the road for the Reds with a 7.04 road ERA. The Reds also have a terrible bullpen that ranks 27th in baseball, so I like the Guardians to take care of business at home in this one.

Nikos Lagouretos's Pick: Cleveland Guardians ML

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