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Cincinnati Reds vs Chicago Cubs Prediction 5/4/2026 Today’s MLB Picks

Apr 11, 2026; Chicago, Illinois, USA; Chicago Cubs pitcher Edward Cabrera (30) pitches against the Pittsburgh Pirates during the first inning at Wrigley Field. Mandatory Credit: Patrick Gorski-Imagn Images

Apr 11, 2026; Chicago, Illinois, USA; Chicago Cubs pitcher Edward Cabrera (30) pitches against the Pittsburgh Pirates during the first inning at Wrigley Field. Mandatory Credit: Patrick Gorski-Imagn Images

MATCHUP Cincinnati Reds Chicago Cubs
Team Records 20-14 22-12
Spread +1.5 -102 -1.5 -118
Moneyline +179 -219
Total Over 11.5 (-102) Under 11.5 (-118)
Where Wrigley Field, Chicago, Illinois
When Monday, May 4, 2026
Time 07:40 PM EDT
TV MLB.TV
In this article, we will formulate a Reds vs Cubs Prediction for this MLB matchup on Monday, May 4th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview


The Chicago Cubs have a 22-12 record this season and are sitting in the first place of the NL Central. They have a 14-5 home record and are coming off an 8-4 home win against the Diamondbacks. Their previous three games were a 2-0 win and a 6-5 win at home against the Diamondbacks, and a 5-4 win on the road against the Padres.

The Cubs have a .261 batting average this season, .353 OBP and .430 Slugging percentage. Chicago’s pitching staff has a 3.89 ERA and 1.17 WHIP. Nico Hoerner is the team’s best hitter with a .301 batting average, also leading the team in RBI with 26. Ian Happ adds a team‑high 8 home runs.

Edward Cabrera (R) is the projected starting pitcher for the Cubs, and he has a 3-0 record, 3.06 ERA and 1.19 WHIP.

Cincinnati Reds Preview


The Cincinnati Reds have a 20-14 record this season and are sitting in the third place of the NL Central. They have a 10-6 away record and are coming off a 0-1 loss on the road against the Pirates. Their previous three games were a 7-17 loss and a 1-9 loss on the road against the Pirates, and a 6-4 win at home against the Rockies.

The Reds have a .217 batting average this season, .304 OBP and .383 Slugging percentage. Cincinnati’s pitching staff has a 4.50 ERA and 1.50 WHIP. Elly De La Cruz is the team’s best hitter with a .271 batting average, also leading the team in RBI with 25. Sal Stewart adds a team‑high 9 home runs.

Chase Petty (R) is the projected starting pitcher for the Reds and last season he had a 0-3 record, 19.50 ERA and 3.67 WHIP.

Cincinnati Reds @ the Chicago Cubs Betting Trends: May 4, 2026


Why the Chicago Cubs will win


Why the Cincinnati Reds will win

Total Runs Facts

Chicago Cubs Player Prop Facts

Cincinnati Reds Player Prop Facts

Matchup/League Facts

Reds vs Cubs Prediction


The Reds are 6-1 in their last 7 meetings against the Cubs but are 2-3 in their last 5 visits in Chicago. Under is 7-2-1 in their last 10 meetings.

In this Reds vs Cubs Prediction, the Cubs are coming as -210 home favorites. The Cubs have been red-hot with five consecutive wins and have a huge pitching advantage with Cabrera on the mound. They also have the second-best offense in baseball and a better bullpen and are facing a Reds team that got swept by the Pirates by 0-3 wins, having allowed 29 earned runs in that span. Take the Cubs on the runline in this one for a comfortable home victory.

Nikos Lagouretos's Pick: Chicago Cubs -1.5

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