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Cincinnati Reds vs Arizona Diamondbacks Prediction 8/21/2026 Today’s MLB Picks

Aug 9, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks pitcher Eduardo Rodriguez in the first inning against the Los Angeles Dodgers at Chase Field. Mandatory Credit: Mark J. Rebilas-Imagn Images

Aug 9, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks pitcher Eduardo Rodriguez in the first inning against the Los Angeles Dodgers at Chase Field. Mandatory Credit: Mark J. Rebilas-Imagn Images

MATCHUP Cincinnati Reds Arizona Diamondbacks
Team Records 61-67 67-61
Spread +1.5 -175 -1.5 144
Moneyline +129 -156
Total Over 8.5 (-102) Under 8.5 (-118)
Where Chase Field, Phoenix, Arizona
When Friday, August 21, 2026
Time 09:40 PM EDT
TV MLB.TV
In this article, we will formulate a Reds vs Diamondbacks Prediction for this MLB matchup on Friday, August 21st in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview


The Arizona Diamondbacks have a 67-61 record this season and are sitting in 3rd place in the NL West. They have a 36-27 home record and are coming off a 7-6 road win against the Red Sox. They will face the Cubs and the Giants next.

The Arizona Diamondbacks have a .243 batting average this season, a .316 OBP, and a .398 slugging percentage. The Diamondbacks’ pitching staff has a 4.18 ERA and a 1.29 WHIP. Gabriel Moreno leads the Diamondbacks with a .307 batting average. Ketel Marte leads the team in RBI with 67 and adds a team-high 21 home runs.

Eduardo Rodriguez (L) is the projected starting pitcher for the Diamondbacks, and he has a 12-4 record, a 2.71 ERA, and a 1.21 WHIP.

Cincinnati Reds Preview


The Cincinnati Reds have a 61-67 record this season and are sitting in 5th place in the NL Central. They have a 29-31 road record and are coming off a 9-10 home loss against the Cardinals. They will face the Giants and the Cubs next.

The Cincinnati Reds have a .226 batting average this season, a .305 OBP, and a .391 slugging percentage. The Reds’ pitching staff has a 4.48 ERA and a 1.40 WHIP. Elly De La Cruz leads the Reds with a .259 batting average. Sal Stewart leads the team in RBI with 96 and adds a team-high 27 home runs.

Nick Lodolo (L) is the projected starting pitcher for the Reds, and he has a 3-2 record, a 4.52 ERA, and a 1.42 WHIP.

Cincinnati Reds @ Arizona Diamondbacks Betting Trends: August 21, 2026


Why the Arizona Diamondbacks will win

Why the Cincinnati Reds will win

Total Runs Facts

Arizona Diamondbacks Player Prop Facts

Cincinnati Reds Player Prop Facts

Matchup/League Facts

Reds vs Diamondbacks Prediction


The Diamondbacks are 4-2 in their last 6 meetings against the Reds and are 3-1 in their last 4 meetings in Arizona.

In this Reds vs Diamondbacks Prediction, the Diamondbacks are coming as -145 home favorites. I like the Dbacks in this one with Eduardo Rodriguez on the mound, who has been the far better pitching option in this matchup than Nick Lodolo. The Dbacks are the best team against lefties this season and their bullpen has been much better lately and will be facing a struggling Reds team that is just 2-6 in its last 8 games. Take the Dbacks to win this one at home.

Nikos Lagouretos's Pick: Arizona Diamondbacks ML

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