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Chicago White Sox vs New York Mets Prediction 5/27/25 MLB Picks

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New York Mets (33-21) vs Chicago White Sox (17-37)

Game Info: Tuesday, May 27, 2025 at 7:10 pm (Citi Field)

The Line: Betting Odds: New York Mets -270 / Chicago White Sox +220 — Over/Under: 7.5

(Get latest betting odds)

The Chicago White Sox are visiting the New York Mets on Tuesday, May 27th at the Citi Field in the second game of this series, with the Mets having a 1-0 lead. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs New York Mets Prediction. We will examine:

The New York Mets’ recent form and player performance

The Chicago White Sox’s recent form and player performance

Recent betting trends and streaks involving the New York Mets

Recent betting trends and streaks involving the Chicago White Sox

Recent betting trends in games played between the Chicago White Sox vs New York Mets

A summary that ties it all together and produces a favorable betting outcome for the Chicago White Sox vs New York Mets game

New York Mets Preview

The New York Mets have a 33-21 record this season and are sitting in second place in the NL East. The Mets have a 20-6 home record and are 18-33 in over/under. They are coming off a 2-1 home victory over the White Sox, and are 4-1 in their last 5 games. Under is 9-2 in their last 11 games, and they are playing the Rockies and the Dodgers next.

The Mets have a .245 batting average this season, a .328 OBP, and a .402 slugging percentage. New York’s pitching staff has a 2.78 ERA and 1.24 WHIP.  Francisco Lindor leads the Mets with 58 hits, adding a team-high 10 home runs. Pete Alonso leads the team in RBI with 40 and in batting average with .291.

Tylor Megill (R) will take the mound for the Mets, and he has a 3-4 record, 3.56 ERA, and 1.35 WHIP. He has been much better at home with a 1.86 ERA across four home starts, and he is coming off a quality start against the Red Sox, where he gave up just one run in 4.2 innings pitched. This will be his first career start against the White Sox.  

Chicago White Sox Preview

The Chicago White Sox have a 17-37 record this season and are sitting in last place in the AL Central. The White Sox have a 5-22 road record and are 24-26 in over/under. They are coming off a 1-2 road defeat by the Mets and have back-to-back losses. They are playing the Orioles and the Tigers next.

The White Sox have a .220 batting average this season, a .291 OBP, and a .341 Slugging percentage. Chicago’s pitching staff has a 4.07 ERA and 1.37 WHIP. Lenyn Sosa leads the White Sox with 49 hits and a team-high .277 batting average. Miguel Vargas leads the team in RBI, with 23, and in home runs, with 7.

Jonathan Cannon (R) will take the mound for the White Sox, and he has a 2-5 record, 3.76 ERA, and 1.31 WHIP. He has been weaker on the road with a 4.76 ERA across five road starts, and he has given up at least two runs in five of his last six starts. In his only previous start against the Mets last season, he gave up 4 runs in 5 innings of work.

Why the New York Mets will win

Why the Chicago White Sox will win

Total Runs Facts

Matchup/League Facts

Chicago White Sox vs New York Mets Prediction

The Mets are 9-1 in their last 10 meetings against the White Sox, and are 3-1 in their last 4 meetings in New York. Under is 10-1 in their last 11 meetings.

In this Chicago White Sox vs New York Mets Prediction, the Mets are coming as huge -270 home favorites. The Mets are rightfully favored, as they have a superior overall record this season and have been extremely strong at home, while the White Sox have been one of the weakest road teams in the league. The Mets also have the third-best bullpen ERA and have a better batting average, while the White Sox are weaker against righties. Megill is coming off a bounce-back performance, while Cannon was torched by the Mets last season, so everything points to an easy Mets win in this one. Take the New York Mets on the runline.

Nikos Lagouretos's Pick: New York Mets -1.5

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