Chicago (52-88) vs Minnesota (62-77)
September 4, 2025 at 07:40 PM EDT
The Line: Betting Odds: Minnesota -149 — Over/Under: +8.5
In this article, we will formulate a White Sox vs Twins Prediction for this MLB game on Thursday, September 4th at the Target Field in the 4th game of this series, with the White Sox having the 3-0 lead. Let’s take a look at the prediction for this MLB matchup.
Minnesota Twins Preview
The Minnesota Twins have a 62-77 record this season and are sitting on the 4th place of the AL Central. The Twins have a 35-35 home record and are 65-65 in over/under. They are coming off a 3-4 home defeat by the White Sox, and are 1-4 in their last 5 games. Over is 11-2 in their last 13 games and are playing the Angels and the Royals next.
The Twins have a .238 batting average this season, .311 OBP and .397 Slugging percentage. Minnesota’s pitching staff has a 4.51 ERA and 1.32 WHIP. Trevor Larnach leads the Twins with 112 hits, while Byron Buxton adds team-highs both in RBI, with 72, and in home runs, with 29. He is also the team’s best hitter with a .273 batting average.
Taj Bradley (R) is the projected starting pitcher for the Twins, and he has a 6-7 record, 4.82 ERA and 1.29 WHIP.
Chicago White Sox Preview
The Chicago White Sox have a 52-88 record this season and are sitting on the last place of the AL Central. The White Sox have a 22-46 road record and are 65-67 in over/under. They are coming off a 4-3 road victory over the Twins, and have four consecutive wins. Over is 6-3 in their last 9 games and are playing the Rays and the Tigers next.
The White Sox have a .234 batting average this season, .303 OBP and .376 Slugging percentage. Chicago’s pitching staff has a 4.20 ERA and 1.37 WHIP. Lenyn Sosa leads the White Sox with 119 hits, and he is the team’s best hitter with a .265 batting average. He also leads the team in RBI with 62, adding a team-high 19 home runs.
Reliever Fraser Ellard (R) is the projected starting pitcher for the White Sox, and he has a 0-2 record, 4.82 ERA and 1.07 WHIP.
White Sox vs Twins Prediction
The White Sox are 6-1 in their last 7 head-to-head meetings against the Twins, and are 4-3 in their last 7 meetings in Minnesota. Over is 4-2 in their last 6 meetings.
In this White Sox vs Twins Prediction, the Twins are coming as -150 home favorites. The Twins are getting embarrassed by the White Sox in this series as both teams have nothing to play for, but Chicago is going for a bullpen game, so this is Minnesota’s chance to salvage a win in this series and avoid the home sweep. Bradley is coming off his best start as a Twin, with one earned run against the Padres, and I think he can carry the momentum against a weak White Sox lineup. Take the Twins for the bounce-back win at home in this one.