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Chicago White Sox vs Kansas City Royals Prediction 5/7/25 MLB Picks

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Kansas City Royals (21-16) vs Chicago White Sox (10-26)

Game Info: Wednesday, May 7, 2025 at 7:40 pm (Kauffman Stadium)

The Line: Betting Odds: Kansas City Royals -225 / Chicago White Sox +185 — Over/Under: 8

(Get latest betting odds)

The Chicago White Sox and Kansas City Royals meet Wednesday in MLB action at Kauffman Stadium. Here’s a Chicago White Sox vs Kansas City Royals Prediction. This article will include a Chicago White Sox vs Kansas City Royals Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 10-26 on the year and play the Marlins, Reds, and Cubs next. The Chicago White Sox are batting .217 on the season, have a .297 OBP, and a .324 slugging percentage. The Chicago White Sox pitching staff has a 4.12 ERA and a 1.38 WHIP. Lenyn Sosa leads the Chicago White Sox with 31 hits and 10 RBI, while Miguel Vargas and Andrew Vaughn have combined for 52 hits and 26 RBI. 

Jonathan Cannon gets the ball for the Chicago White Sox, and he is 2-3 with a 4.26 ERA and 32 strikeouts this season. Cannon is 0-1 with a 3.00 ERA and 9 strikeouts in his career against the Kansas City Royals.

Kansas City Royals Betting Preview

The Kansas City Royals are 21-16 on the year and play the Red Sox, Astros, and Cardinals next. The Kansas City Royals are batting .238 on the season, have a .300 OBP, and a .360 slugging percentage. The Kansas City Royals pitching staff has a 3.04 ERA and a 1.20 WHIP. Bobby Witt Jr. leads the Kansas City Royals with 44 hits and 19 RBI, while Maikel Garcia and Salvador Perez have combined for 70 hits and 32 RBI.

Michael Wacha gets the ball for the Kansas City Royals, and he is 1-4 with a 3.52 ERA and 29 strikeouts this season. Wacha is 5-1 with a 3.21 ERA and 53 strikeouts in his career against the Chicago White Sox.

Why the Kansas City Royals will win

Why the Chicago White Sox will win

Kansas City Royals Player Prop Facts

Chicago White Sox Player Prop Facts

Chicago White Sox vs Kansas City Royals Prediction

As I’ve said time and time again this season, I want absolutely nothing to do with the White Sox. They’ve been the worst team in baseball over the last three years and continue to burn a hole in bettors’ pockets. Cannon isn’t changing much, especially when he has a 6.35 ERA and .244 allowed batting average in 22.2 road innings. The Royals have been on fire over the last couple of weeks, and that shouldn’t stop here against a downright terrible franchise. Wacha has been respectable this season, which includes allowing 11 hits and three runs in his last 12.1 innings. The White Sox do nothing for me, and we’ve been making a killing fading them over the years. Give me the Royals and the RL for max betting value.

Randy Chambers's Pick: Kansas City Royals -1.5

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