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Chicago White Sox vs Cleveland Guardians Prediction 9/14/2026 Today’s MLB Picks

Sep 13, 2026; St. Louis, Missouri, USA;  Chicago White Sox first baseman Munetaka Murakami (5) fields a ground ball against the St. Louis Cardinals during the first inning at Busch Stadium.  Mandatory Credit: Jeff Le-Imagn Images

Sep 13, 2026; St. Louis, Missouri, USA; Chicago White Sox first baseman Munetaka Murakami (5) fields a ground ball against the St. Louis Cardinals during the first inning at Busch Stadium. Mandatory Credit: Jeff Le-Imagn Images

MATCHUP Chicago White Sox Cleveland Guardians
Team Records 76-73 76-74
Spread +1.5 -185 -1.5 152
Moneyline +129 -156
Total Over 7 (-102) Under 7 (-118)
Where Progressive Field, Cleveland, Ohio
When Monday, September 14, 2026
Time 06:40 PM EDT
TV ESPN Unlmtd
The Chicago White Sox and Cleveland Guardians meet Monday in MLB action at Progressive Field. Here’s a Chicago White Sox vs. Cleveland Guardians Prediction. This article will include a Chicago White Sox vs Cleveland Guardians Pick.

Chicago White Sox Betting Preview


The Chicago White Sox are 76-73 on the year and play the Tigers and Royals next. The Chicago White Sox are batting .235 on the season, have a .318 OBP, and have a .403 slugging percentage. The Chicago White Sox pitching staff has a 4.13 ERA and a 1.31 WHIP. Chase Meidroth leads the Chicago White Sox with 140 hits and 54 RBI, while Sam Antonacci and Miguel Vargas have combined for 254 hits and 123 RBI.

Sean Newcomb gets the ball for the Chicago White Sox, and he is 2-4 with a 2.77 ERA and 78 strikeouts this season. Newcomb is 0-1 with a 0.87 ERA and 13 strikeouts in his career against the Cleveland Guardians.

Cleveland Guardians Betting Preview


The Cleveland Guardians are 76-74 on the year and play the Red Sox and Athletics next. The Cleveland Guardians are batting .237 this season, with a .315 OBP and a .374 slugging percentage. The Cleveland Guardians pitching staff has a 3.78 ERA and a 1.26 WHIP. Steven Kwan leads the Cleveland Guardians with 139 hits and 30 RBI, while Chase DeLauter and Brayan Rocchio have combined for 257 hits and 127 RBI.

Gavin Williams is 13-7 with a 3.78 ERA and 228 strikeouts this season. Williams is 1-1 with a 4.91 ERA and 35 strikeouts in his career against the Chicago White Sox.

Why the Cleveland Guardians will win

Why the Chicago White Sox will win

Total Runs Facts

Cleveland Guardians Player Prop Facts

Chicago White Sox Player Prop Facts

Matchup/League Facts

Chicago White Sox vs Cleveland Guardians Prediction


This series is crucial to who wins the AL Central, and the Guardians should have the edge at home. However, I’ve backed the White Sox a ton this season, and they’ve rewarded me by being the third most profitable team in baseball. The White Sox haven’t gotten respect all season, but they’ve turned a profit only the Brewers and Rays have topped. Williams has been solid, but you can argue Newcomb has been better with a 2.77 ERA and 1.14 WHIP. Like I have all season, I’m going to grab the White Sox at the more favorable price.

Randy Chambers's Pick: Chicago White Sox

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