Chicago White Sox vs Chicago Cubs Prediction 5/17/25 MLB Picks

The Chicago White Sox and the Chicago Cubs meet Saturday in MLB action from Wrigley Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago White Sox vs. Chicago Cubs prediction.

Starting Pitching Matchup

The Chicago White Sox will send out Sean Burke for the start here, and Burke is 2-4 with a 4.15 ERA and 29 strikeouts this season. This will be Burke’s first career start against the Cubs. The Chicago Cubs will trot out Matthew Boyd for the start here, and Boyd is 3-2 with a 2.78 ERA and 45 strikeouts this season. In his last five starts against the White Sox, Boyd is 0-3 with a 6.63 ERA and 34 strikeouts.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back after taking a 13-3 loss at the hands of the Cubs in Friday’s opener to fall to 14-31 on the year. After this series, the White Sox will head home for a series against the Seattle Mariners.

White Sox Drop Back-To-Back Games

Lenyn Sosa leads the White Sox with 40 hits, including 7 doubles and 11 RBIs. Andrew Benintendi has 19 hits, including 5 home runs, 12 RBIs, and a .224 batting average, while Miguel Vargas has a team-high 9 doubles and 16 RBIs. Brooks Baldwin has also added 16 RBIs, while Luis Robert Jr. has a team-high 17 stolen bases along with 17 RBIs so far this season. Andrew Vaughn has 5 home runs and 18 RBIs as well as 8 doubles this season.

Why the Chicago White Sox will win

• The Cubs have lost four of their last five games as favorites against American League opponents following a home win.
• The White Sox have won three of their last four games as underdogs against National League opponents following a loss.
• The Cubs have failed to cover the run line in each of their last 10 games as home favorites against AL Central opponents following a win.
• The White Sox have covered the run line in six of their last seven road games against the Cubs following a loss.

Chicago White Sox Player Prop Facts

• Miguel Vargas has hit at least one home run in six of his last seven appearances against NL Central opponents that held a winning record.
• Miguel Vargas has recorded at least one RBI in six of his last seven appearances against NL Central opponents that held a winning record.
• Andrew Benintendi has recorded at least one hit in each of his last seven appearances against NL Central opponents that held a winning record.
• Andrew Benintendi has scored a run in each of his last five appearances.
• Andrew Benintendi has recorded a Double in each of his five previous appearances at Wrigley Field.
• Josh Rojas has recorded at least one Single in each of his last four appearances in day games against NL teams that held a winning record.
• Luis Robert ranks 1st in the league in Steals (17) this season.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to add on to their win over the White Sox on Friday to improve their record to 26-19 on the year. After this series, the Cubs will head on the road for a rematch series against the Marlins.

Cubs Win Four Of Their Last Six

Ian Happ has 43 hits with 9 doubles, 3 home runs, and 19 RBIs. Kyle Tucker has 45 hits, including 9 doubles, 3 triples, 10 home runs, and 33 RBIs, while Seiya Suzuki also has 39 hits with 7 doubles and 11 home runs and 35 RBIs of his own. Miguel Amaya added 8 doubles and 18 RBIs, and Pete Crow-Armstrong also has contributed 45 hits, 11 doubles, 11 home runs, and 30 RBIs as well this season. Dansby Swanson has added 9 home runs and 24 RBIs, while Suzuki has the unfortunate distinction of leading the Cubs with 52 strikeouts so far this season. Crow-Armstrong also has a team-high 13 stolen bases, while Nico Hoerner has 8 stolen bases this season. Tucker’s also added 10 stolen bases, while Michael Busch has also chipped in 7 home runs and 24 RBIs this season.

Why the Chicago Cubs will win

• The Cubs have won each of their last seven day games against AL Central opponents.
• The White Sox have lost 12 of their last 13 road games against National League opponents that held a winning record.
• The Cubs have covered the run line in each of their last five day games against AL Central opponents.
• The White Sox have failed to cover the run line in each of their last six Saturday games against National League opponents.

Chicago Cubs Player Prop Facts

• Nico Hoerner has recorded at least one Double in each of the Cubs’ last three day games.
• Seiya Suzuki has hit at least one home run in three of the Cubs’ last five day games against opponents that held a losing record.
• Matthew Boyd has recorded a win in each of his last three home appearances.
• Seiya Suzuki has recorded at least one RBI in each of the Cubs’ last eight games against AL opponents.
• Nico Hoerner has recorded at least one Single in each of the Cubs’ last eight games against AL opponents that held a losing record.
• Seiya Suzuki has scored at least one run in each of the Cubs’ last seven games against AL opponents.
• Matthew Boyd has recorded six or more strikeouts in each of his last four appearances against AL Central opponents that held a losing record.
• Seiya Suzuki has recorded at least one hit in each of the Cubs’ last 11 games as favorites against AL opponents.
• Pete Crow-Armstrong ranks T5th in the league in Steals (13) this season.

Total Runs Facts

• Each of the Cubs’ last eight games against American League opponents have gone OVER the total runs line.
• Five of the White Sox’s last six games have gone UNDER the total runs line.

Chicago White Sox vs. Chicago Cubs Prediction

I’m on the Cubs here. I think the White Sox’s best shot at a win in this series came yesterday with Shane Smith on the mound, as he’s been their best arm this season, but despite that, the White Sox are 1-8 in Smith’s starts this season. Why? Because Smith doesn’t get any run support, and I don’t think Burke will either against a lefty in Boyd, who has been solid as of late. I’ll roll with the Cubs in this one.

Chris Ruffolo's Pick: Chicago Cubs -278