Chicago White Sox vs Baltimore Orioles Prediction 5/30/25 MLB Picks

The Chicago White Sox and Baltimore Orioles meet Friday in MLB action at Oriole Park at Camden Yards. Here’s a Chicago White Sox vs Baltimore Orioles Prediction. This article will include a Chicago White Sox vs Baltimore Orioles Pick.

Chicago White Sox Betting Preview

The Chicago White Sox are 18-38 on the year and play the Tigers, Royals, and Astros next. The Chicago White Sox are batting .221 on the season, have a .294 OBP, and a .344 slugging percentage. The Chicago White Sox pitching staff has a 4.13 ERA and a 1.38 WHIP. Lenyn Sosa leads the Chicago White Sox with 52 hits and 17 RBI, while Miguel Vargas and Andre Vaughn have combined for 83 hits and 45 RBI. 

Sean Burke gets the ball for the Chicago White Sox, and he is 3-5 with a 4.33 ERA and 39 strikeouts this season. This will be Burke’s first career game against the Baltimore Orioles.

Baltimore Orioles Betting Preview

The Baltimore Orioles are 19-36 on the year and play the Mariners, Athletics, and Tigers next. The Baltimore Orioles are batting .237 on the season, have a .303 OBP, and a .386 slugging percentage. The Baltimore Orioles pitching staff has a 5.49 ERA and a 1.48 WHIP. Ryan O’Hearn leads the Baltimore Orioles with 54 hits and 21 RBI, while Jackson Holliday and Gunnar Henderson have combined for 99 hits and 39 RBI.

Zach Eflin gets the ball for the Baltimore Orioles, and he is 3-2 with a 5.40 ERA and 18 strikeouts this season. Eflin is 2-1 with a 2.88 ERA and 18 strikeouts in his career against the Chicago White Sox.

Why the Baltimore Orioles will win

• The White Sox have lost 12 of their last 13 road games against American League opponents following a road win.
• The Orioles have won six of their last seven home games against AL Central opponents that held a losing record.
• The White Sox have failed to cover the run line in seven of their last eight games as road underdogs against AL East opponents following a win.
• The Orioles have covered the run line in six of their last seven games against the White Sox.
• The Orioles have led after 5 innings in five of their last six games at Oriole Park at Camden Yards against AL Central opponents that held a losing record.
• The Orioles have led after 3 innings in five of their last six home games against AL Central opponents that held a losing record.

Why the Chicago White Sox will win

• The Orioles have lost each of their last seven games as home favorites following a home loss.
• The underdogs have won five of the Orioles’ last six games.
• The Orioles have failed to cover the run line in each of their last nine games as favorites following a home loss.
• The underdogs have covered the run line in 10 of the Orioles’ last 11 games at Oriole Park at Camden Yards.
• The White Sox have led after 5 innings in six of their last eight night games.

Baltimore Orioles Player Prop Facts

• Ryan Mountcastle has recorded a Double in three of his last four appearances with the Orioles as favorites against the White Sox.
• Gunnar Henderson has hit a home run in five of the Orioles’ last six games at Oriole Park at Camden Yards against AL Central opponents that held a losing record.
• Zach Eflin has recorded five or more strikeouts in three of his last four appearances against AL opponents that held a losing record.
• Gunnar Henderson has recorded at least one RBI in six of the Orioles’ last seven home games against AL Central opponents that held a losing record.
• Ramon Urias has recorded at least one Single in each of his last six appearances at Oriole Park at Camden Yards against AL opponents that held a losing record.
• Gunnar Henderson has scored at least one run in each of the Orioles’ last six games against the White Sox at Oriole Park at Camden Yards.
• Ryan Mountcastle has recorded at least one hit in each of the Orioles’ last nine games against AL opponents that held a losing record.
• Ryan O’Hearn ranks 6th amongst qualified players for Batting Average (.338) this season.

Chicago White Sox Player Prop Facts

• Miguel Vargas has recorded a Double in each of the White Sox’s last five games as underdogs.
• Luis Robert has recorded an RBI in four of the White Sox’s last five games against opponents that held a losing record.
• Mike Tauchman has scored at least one run in five of the White Sox’s last six games.
• Luis Robert has recorded two hits in four of his last five appearances against the Orioles.
• Andrew Vaughn has hit a home run in two of his last three appearances against the Orioles at Oriole Park at Camden Yards.
• Michael A. Taylor has recorded at least one Single in eight of his 10 previous appearances at Oriole Park at Camden Yards against opponents that held a losing record.

Chicago White Sox vs Baltimore Orioles Prediction

Two teams we’ve been fading all year, so I’m not excited to back either of these teams. The Orioles should be favored because they’re the better team on paper and at home. The White Sox are dreadful and the worst team in baseball over the last three years. With that said, this line is insane. Burke has allowed eight earned runs in his last 27 innings, while Eflin has allowed 20 hits and 14 earned runs in his last 15.1 innings. If forced to pick a side, I want the plus money, and it doesn’t hurt that we’re getting the pitcher in much better form. Give me the White Sox at this price.

Randy Chambers's Pick: Chicago White Sox +185