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Chicago Cubs vs St. Louis Cardinals Prediction 5/31/2026 Today’s MLB Picks

May 30, 2026; St. Louis, Missouri, USA; Chicago Cubs second baseman Nico Hoerner (2) hits an RBI single against the St. Louis Cardinals during the sixth inning at Busch Stadium. Mandatory Credit: Jeff Le-Imagn Images

May 30, 2026; St. Louis, Missouri, USA; Chicago Cubs second baseman Nico Hoerner (2) hits an RBI single against the St. Louis Cardinals during the sixth inning at Busch Stadium. Mandatory Credit: Jeff Le-Imagn Images

MATCHUP Chicago Cubs St. Louis Cardinals
Team Records 32-27 30-26
Spread -1.5 139 +1.5 -168
Moneyline -114 -105
Total Over 8.5 (-118) Under 8.5 (-102)
Where Busch Stadium, St. Louis, Missouri
When Sunday, May 31, 2026
Time 07:20 PM EDT
TV NBC
The Chicago Cubs and St. Louis Cardinals meet Sunday in MLB action at Busch Stadium. Here’s a Chicago Cubs vs St. Louis Cardinals Prediction. This article will include a Chicago Cubs vs St. Louis Cardinals Pick.

Chicago Cubs Betting Preview


The Chicago Cubs are 32-27 on the year and play the Athletics and Giants next. The Chicago Cubs are batting .240 on the season and have a .337 OBP and a .389 slugging percentage. The Chicago Cubs’ pitching staff has a 4.17 ERA and a 1.23 WHIP. Alex Bregman leads the Chicago Cubs with 61 hits and 17 RBI, while Pete Crow-Armstrong and Nico Hoerner have combined for 110 hits and 59 RBI.

Jordan Wicks gets the ball for the Chicago Cubs, and he is 0-1 with a 16.62 ERA and 5 strikeouts this season. Wicks is 0-0 with a 0.00 ERA and 8 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview


The St. Louis Cardinals are 30-26 on the year and play the Reds and Rangers next. The St. Louis Cardinals are batting .238 on the season, with a .317 OBP and a .384 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.21 ERA and a 1.37 WHIP. Jordan Walker leads the St. Louis Cardinals with 61 hits and 42 RBI, while Alec Burleson and Ivan Herrera have combined for 114 hits and 63 RBI.

Matthew Liberatore gets the ball for the St. Louis Cardinals, and he is 2-3 with a 4.76 ERA and 53 strikeouts this season. Liberatore is 1-1 with a 3.70 ERA and 22 strikeouts in his career against the Chicago Cubs.

Why the St. Louis Cardinals will win

Why the Chicago Cubs will win

Total Runs Facts

St. Louis Cardinals Player Prop Facts

Chicago Cubs Player Prop Facts

Chicago Cubs vs St. Louis Cardinals Prediction


Liberatore is the more trustworthy option, given he has 56.2 innings under his belt. Wicks has been a disaster, but he has just 4.1 innings this season. The jury is still out. With that said, the pitching matchup means nothing if the Cardinals can’t score runs and the bats have been quiet all week. The Cardinals have scored 2 or fewer runs in 7 of their last 11 games. Because the Cardinals can’t string offense together, I’m going to roll with the Cubs on Sunday night baseball.

Randy Chambers's Pick: Chicago Cubs

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