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Chicago Cubs vs Chicago White Sox Prediction 5/17/2026 Today’s MLB Picks

May 16, 2026; Chicago, Illinois, USA;  Chicago White Sox first baseman Munetaka Murakami (5) pumps his fist after hitting a home run during the third inning against the Chicago Cubs at Rate Field. Mandatory Credit: Matt Marton-Imagn Images

May 16, 2026; Chicago, Illinois, USA; Chicago White Sox first baseman Munetaka Murakami (5) pumps his fist after hitting a home run during the third inning against the Chicago Cubs at Rate Field. Mandatory Credit: Matt Marton-Imagn Images

MATCHUP Chicago Cubs Chicago White Sox
Team Records 29-17 23-22
Spread -1.5 119 +1.5 -143
Moneyline -143 +119
Total Over 8.5 (-114) Under 8.5 (-105)
Where Rate Field, Chicago, Illinois
When Sunday, May 17, 2026
Time 02:10 PM EDT
TV MLB.TV
The Chicago Cubs and Chicago White Sox meet Sunday in MLB action at Wrigley Field. Here’s a Chicago Cubs vs. Chicago White Sox Prediction. This article will include a Chicago Cubs vs. Chicago White Sox Pick.

Chicago Cubs Betting Preview


The Chicago Cubs are 29-17 on the year and play the Brewers and Astros next. The Chicago Cubs are batting .247 on the season and have a .341 OBP, and a .406 slugging percentage. The Chicago Cubs’ pitching staff has a 3.90 ERA and a 1.19 WHIP. Nico Hoerner leads the Chicago Cubs with 48 hits and 29 RBI, while Alex Bregman and Pete Crow-Armstrong have combined for 86 hits and 34 RBI.

Colin Rea gets the ball for the Chicago Cubs, and he is 4-2 with a 4.68 ERA and 36 strikeouts this season. Rea is 0-0 with a 2.45 ERA and 5 strikeouts in his career against the Chicago White Sox.

Chicago White Sox Betting Preview


The Chicago White Sox are 23-22 on the year and play the Mariners and Giants next. The Chicago White Sox are batting .234 on the season, have a .324 OBP, and have a .401 slugging percentage. The Chicago White Sox pitching staff has a 4.32 ERA and a 1.37 WHIP. Chase Meidroth leads the Chicago White Sox with 43 hits and 10 RBI, while Colson Montgomery and Miguel Vargas have combined for 77 hits and 58 RBI.

Erick Fedde gets the ball for the Chicago White Sox, and he is 0-4 with a 3.77 ERA and 26 strikeouts this season. Fedde is 0-3 with an 8.53 ERA and 28 strikeouts in his career against the Chicago Cubs.

Why the Chicago White Sox will win

Why the Chicago Cubs will win

Total Runs Facts

Chicago White Sox Player Prop Facts

Chicago Cubs Player Prop Facts

Matchup/League Facts

Chicago Cubs vs Chicago White Sox Prediction


The Cubs have cooled off over the last week and Rea hasn’t been great through 42.1 innings with a 4.68 ERA and 1.42 WHIP. Fedde has been sharper through 43 innings with a 3.77 ERA and 1.16 WHIP. Fedde needs to do a better job of keeping the ball in the park but outside of that, he’s been sharp. The White Sox, overall, are winning for once and have a chance to keep making a statement to the rest of the league. They’ve had fun this series and should be able to finish it off strong. I’m going to keep backing the White Sox.

Randy Chambers's Pick: Chicago White Sox

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