Blue Jays vs Cubs Prediction 6/21/2026 Today’s MLB Picks

In this article we will formulate a Blue Jays vs Cubs prediction for this MLB game on Sunday, June 21st at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Toronto Blue Jays Betting Preview

The Toronto Blue Jays are 38-39 this season after they split the first two games in this series by scores of 2-16 and 8-6. In game two, Toronto trailed 5-0 in the sixth inning, but they scored the next eight runs for the comeback win. The Blue Jays recorded nine hits and they committed two errors in the game, while they were led by Varsho, who went 1-4 with one home run and three RBIs. Corbin allowed six hits and three earned runs over 3.2 innings, while Hoffman picked up the win in relief. Prior to this series, Toronto won all three against the Red Sox, but lost two out of three against the Yankees before that. 

This season, Toronto has a 4.13 ERA with a 1.31 WHIP and a .242 opponent batting average, while they have scored 316 runs with a .249 batting average and a .311 on base percentage. Kazuma Okamoto has led the Blue Jays with 16 home runs and 45 RBIs, while Andres Gimenez has added seven home runs and 33 RBIs. The projected starting pitcher for Toronto is Dylan Cease, who is 4-3 with a 2.71 ERA and a 1.19 WHIP over 73.0 innings pitched this season. 

Chicago Cubs Betting Preview

The Chicago Cubs are 40-37 this year after they lost game two by a score of 8-6 on Saturday. Chicago led 5-0 in the sixth inning and they were cruising to the win, but the bullpen fell apart for the tough loss. The Cubs recorded nine hits in the game and they were led by Shaw, who went 1-5 with one home run and three RBIs. Rea allowed three hits and zero earned runs over 5.1 innings, while Webb allowed three earned runs for the loss. Prior to this series, Chicago won two out of three against the Rockies and two out of three against the Giants. 

This season, Chicago has a 4.28 ERA with a 1.24 WHIP and a .240 opponent batting average, while they have scored 366 runs with a .244 batting average and a .337 on base percentage. Michael Busch has led the Cubs with eight home runs and 42 RBIs, while Ian Happ has added 16 home runs and 37 RBIs. The projected starting pitcher for Chicago is Shota Imanaga, who is 4-6 with a 4.26 ERA and a 1.06 WHIP over 86.2 innings pitched this year. 

Why the Chicago Cubs will win

• The Cubs have won five of their last six games as home underdogs against American League opponents following a home loss.
• The Blue Jays have lost five of their last seven games as favorites against NL Central opponents following a win.
• The underdogs have covered the run line in six of the Blue Jays’ last seven games at Wrigley Field.
• The Blue Jays have failed to cover the run line in 10 of their last 12 games as favorites against National League opponents following a win.
• The Cubs have led after 3 innings in seven of their last eight home games against AL East opponents that held a losing record.
• The Cubs have led after 5 innings in 10 of their last 12 home games against AL East opponents.

Why the Toronto Blue Jays will win

• The Cubs have lost each of their last six day games against American League opponents following a loss.
• The Blue Jays have won five of their last six road games.
• The Cubs have failed to cover the run line in each of their last seven games against American League opponents after playing the previous day.
• The Blue Jays have covered the run line in 10 of their last 11 day games against National League opponents that held a winning record.
• The Cubs have trailed after 5 innings in six of their last eight day games against American League opponents that held a losing record.

Total Runs Facts

• Each of the Cubs’ last four home games against American League opponents have gone OVER the total runs line.
• Five of the Blue Jays’ last six games as favorites have gone OVER the total runs line.
• There has been at least one run scored in the first inning in 10 of Dylan Cease’s last 12 road appearances as a starter.
• There has been at least one run scored in the first inning in four of the Cubs’ last five games as home underdogs.

Chicago Cubs Player Prop Facts

• Seiya Suzuki has recorded at least one hit in each of his last eight home appearances after playing the previous day.
• Ian Happ has hit a home run in two of the Cubs’ last three games as home underdogs.

Toronto Blue Jays Player Prop Facts

• Dylan Cease has recorded seven or more strikeouts in eight of his last nine appearances.
• Dylan Cease has recorded a win in three of his last four road appearances.
• Daulton Varsho has recorded at least one hit in each of his 10 previous road appearances against the Cubs.
• George Springer has hit at least one home run in five of his last six appearances with the Blue Jays as road favorites against NL Central opponents.

Blue Jays vs Cubs Prediction 

Toronto was able to bounce back from a very rough game one with a great comeback win in game two and they have won four of their last five games. The Blue Jays are 17-21 on the road this year, while the Cubs are 23-17 at home. Chicago has won three of their last five games and they have scored 30 runs in their last three. The Cubs are starting Imanaga, who has allowed one earned run in his last 10.2 innings, while Cease has allowed two earned runs or fewer in four of his last five starts. This should be a great game, but I am siding with the Cubs at home.

David Racey's Pick: Cubs ML