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Baltimore Orioles vs Washington Nationals Prediction 5/16/2026 Today’s MLB Picks

Mar 30, 2026; Baltimore, Maryland, USA; Baltimore Orioles pitcher Chris Bassitt (40) throws during the first inning against the Texas Rangers at Oriole Park at Camden Yards. Mandatory Credit: Daniel Kucin Jr.-Imagn Images

Mar 30, 2026; Baltimore, Maryland, USA; Baltimore Orioles pitcher Chris Bassitt (40) throws during the first inning against the Texas Rangers at Oriole Park at Camden Yards. Mandatory Credit: Daniel Kucin Jr.-Imagn Images

MATCHUP Baltimore Orioles Washington Nationals
Team Records 20-25 22-23
Spread -1.5 141 +1.5 -171
Moneyline -110 -110
Total Over 10 (-113) Under 10 (-107)
Where Nationals Park, Washington, District of Columbia
When Saturday, May 16, 2026
Time 04:05 PM EDT
TV MLB.TV
In this article, we will formulate an Orioles vs Nationals Prediction for this MLB matchup on Saturday, May 16th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Washington Nationals Preview


The Washington Nationals have a 22-23 record this season and are sitting in the third place of the NL East. They have a 7-13 home record and are coming off a 3-2 home win against the Orioles. They will face the Mets and the Braves next.

The Nationals have a .241 batting average this season, .322 OBP and .407 Slugging percentage. Washington’s pitching staff has a 4.95 ERA and 1.43 WHIP. CJ Abrams is the team’s best hitter with a .291 batting average, also leading the team in RBI with 36. James Wood adds a team‑high 12 home runs.

Cade Cavalli (R) is the projected starting pitcher for the Nationals, and he has a 1-2 record, 4.02 ERA and 1.59 WHIP.

Baltimore Orioles Preview


The Baltimore Orioles have a 20-25 record this season and are sitting in the third place of the AL East. They have a 8-13 away record and are coming off a 2-3 loss on the road against the Nationals. They will face the Rays and the Tigers next.

The Orioles have a .230 batting average this season, .315 OBP and .375 Slugging percentage. Baltimore’s pitching staff has a 4.58 ERA and 1.42 WHIP. Taylor Ward is the team’s best hitter with a .265 batting average. Jeremiah Jackson leads the team in RBI with 25, and Gunnar Henderson adds a team‑high 9 home runs.

Chris Bassitt (R) is the projected starting pitcher for the Orioles, and he has a 3-2 record, 5.21 ERA and 1.74 WHIP.

Baltimore Orioles @ Washington Nationals Betting Trends: May 16, 2026


Why the Washington Nationals will win


Why the Baltimore Orioles will win

Total Runs Facts

Washington Nationals Player Prop Facts

Baltimore Orioles Player Prop Facts

Matchup/League Facts

Orioles vs Nationals Prediction


The Nationals are 9-1 in their last 10 meetings against the Orioles and are 6-1 in their last 7 meetings in Washington.

In this Orioles vs Nationals Prediction, both teams are coming at a pickem price. I like Cavalli in this matchup as he has been more stable than Bassitt and better at home. Bassitt has given up 4+ runs in two of his last three starts, has been terrible on the road and he is facing the second-best offense in baseball. I cannot trust this Orioles squad on the road with Bassitt on the mound, so I will take the Nationals on the moneyline in this one to win another one at home.

Nikos Lagouretos's Pick: Washington Nationals ML

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