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Baltimore Orioles vs Pittsburgh Pirates Prediction 4/5/2026 Today’s MLB Picks

Mar 30, 2026; Baltimore, Maryland, USA; Baltimore Orioles pitcher Chris Bassitt (40) looks on during the fifth inning against the Texas Rangers at Oriole Park at Camden Yards. Mandatory Credit: Daniel Kucin Jr.-Imagn Images

Mar 30, 2026; Baltimore, Maryland, USA; Baltimore Orioles pitcher Chris Bassitt (40) looks on during the fifth inning against the Texas Rangers at Oriole Park at Camden Yards. Mandatory Credit: Daniel Kucin Jr.-Imagn Images

MATCHUP Baltimore Orioles Pittsburgh Pirates
Team Records 3-6 6-3
Where PNC Park, Pittsburgh, Pennsylvania
When Sunday, April 5, 2026
Time 01:35 PM EDT
TV MLB.TV

In this article, we will formulate an Orioles vs Pirates Prediction for this MLB matchup on Sunday, April 5th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Pittsburgh Pirates Preview

The Pittsburgh Pirates have a 5-3 record this season and are sitting in the second place of the NL Central. They have a 2-0 home record and are coming off a 3-2 home win against the Orioles. Their previous three games were a 5-4 home win against the Orioles, and two 8-3 road wins against the Reds.

The Pirates have a .232 batting average this season, .326 OBP and .384 Slugging percentage. Pittsburgh’s pitching staff has a 3.50 ERA and 1.39 WHIP. Ryan O’Hearn is the team’s best hitter with a .360 batting average, also leading the team in RBI with 7. Oneil Cruz adds a team-high three home runs.

Braxton Ashcraft (R) is the projected starting pitcher for the Pirates, and he has a 0-1 record, 3.00 ERA and 1.33 WHIP.

Baltimore Orioles Preview

The Baltimore Orioles have a 3-5 record this season and are sitting in the third place of the AL East. They have a 0-2 road record and are coming off a 2-3 road loss against the Pirates. Their previous three games were a 4-5 road loss against the Pirates, an 8-3 home win and a 5-8 home loss against the Rangers.

The Orioles have a .249 batting average this season, .337 OBP and .368 Slugging percentage. Baltimore’s pitching staff has a 4.22 ERA and 1.42 WHIP. Adley Rutschman is the team’s best hitter with a .333 batting average. Gunnar Henderson leads the team in RBI with 6, also adding a team-high two home runs.

Chris Bassitt (R) is the projected starting pitcher for the Orioles, and he has a 0-1 record, 8.31 ERA and 2.31 WHIP.

Baltimore Orioles @ Pittsburgh Pirates Betting Trends: April 5, 2026

Why the Pittsburgh Pirates will win

Why the Baltimore Orioles will win

Total Runs Facts

Pittsburgh Pirates Player Prop Facts

Baltimore Orioles Player Prop Facts

Matchup/League Facts

Orioles vs Pirates Prediction

Both teams are tied 5-5 in their last 10 meetings but the Pirates have won their last four meetings in Pittsburgh.  

In this Orioles vs Pirates Prediction, the Pirates are coming as -130 home favorites. The Pirates have four consecutive wins and will face Chris Bassitt for the Orioles, who had a rough start to the season. The Pirates also have a better bullpen ERA and score more runs and I don’t see the Orioles bouncing back in this one, as Bassitt has been historically weaker on the road, having a 5.47 road ERA last season. Take the Pirates on the moneyline.

Nikos Lagouretos's Pick: Pittsburgh Pirates ML

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