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Athletics vs Chicago White Sox Prediction 4/16/25 MLB Picks

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Chicago White Sox (4-12) vs Athletics (7-10)

Game Info: Wednesday, April 16, 2025 at 7:40 pm (Rate Field)

The Line: Betting Odds: Chicago White Sox +130 / Athletics -155 — Over/Under: 7.5

(Get latest betting odds)

The Athletics and the Chicago White Sox meet Wednesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Athletics vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Athletics will send out Osvaldo Bido for the start here, and Bido is 1-1 with a 3.00 ERA and 14 strikeouts this season. This will be Bido’s first career start against the White Sox. The Chicago White Sox will start Jonathan Cannon here, and Cannon is 0-2 with a 5.79 ERA and 14 strikeouts this season. This will be Cannon’s second career start against the Athletics.

Athletics Recap

The Athletics will be out to build on their series-opening 12-3 win over the White Sox on Tuesday to improve to 7-10 on the year. After this series, the Athletics will head on the road for a series against the Milwaukee Brewers.

Athletics Looking For Some Consistency After Splitting Last Ten Games

Jacob Wilson leads the Athletics with 22 hits, 4 doubles, and a .333 batting average, while Tyler Soderstrom has 21 hits with 8 home runs and 17 RBIs this season. Brent Rooker has 15 hits with 4 home runs and 8 RBIs but also has a team-high 22 strikeouts this season, while Max Muncy has 16 strikeouts. Lawrence Butler also chipped in a pair of stolen bases and 4 doubles as part of his 18 hits.

Why the Athletics will win

Athletics Player Prop Facts

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound after a blowout loss at the hands of the Athletics in Tuesday’s series opener to fall to 4-12 on the year. After this series, the White Sox will head on the road for a series against the Boston Red Sox.

White Sox Drop Back-To-Back Games

Lenyn Sosa leads the White Sox with 12 hits, including a pair of doubles and 5 RBIs. Andrew Benintendi has 9 hits, including 2 home runs, 6 RBIs, and a .290 batting average, while Miguel Vargas has a team-high 4 doubles and 6 RBIs. Brooks Baldwin has also added 7 RBIs while Luis Robert Jr. has a team-high 6 stolen bases so far this season. Nick Maton also has a pair of home runs for the White Sox, while Andrew Vaughn has a team-high 2 home runs and 8 RBIs as well this season.

Why the Chicago White Sox will win

Chicago White Sox Player Prop Facts

Total Runs Facts

Athletics vs. Chicago White Sox Prediction

I’m on the Athletics in this one. I’m all about making a case for an underdog in certain spots, but the Athletics for me are just the better team playing some solid baseball out of the gate, and while I’m not the biggest Osvaldo Bido fan, he’s the better option here. The Athletics offense can be boom or bust, but as we saw on Tuesday, when the bats are clicking, the Athletics have a lot of upside. I think the Athletics grab another one here so give me the Athletics on the road here.

Chris Ruffolo's Pick: Athletics -155

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