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Athletics vs Arizona Diamondbacks Prediction 7/22/2026 Today’s MLB Picks

Jul 21, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks second baseman Ildemaro Vargas (left) throws to first base to complete the double play after forcing out sliding Athletics base runner Tyler Soderstrom in the third inning at Chase Field. Mandatory Credit: Mark J. Rebilas-Imagn Images

Jul 21, 2026; Phoenix, Arizona, USA; Arizona Diamondbacks second baseman Ildemaro Vargas (left) throws to first base to complete the double play after forcing out sliding Athletics base runner Tyler Soderstrom in the third inning at Chase Field. Mandatory Credit: Mark J. Rebilas-Imagn Images

MATCHUP Oakland Athletics Arizona Diamondbacks
Team Records 42-57 52-49
Spread -1.5 160 +1.5 -195
Moneyline -102 -118
Total Over 9 (-115) Under 9 (-105)
Where Chase Field, Phoenix, Arizona
When Wednesday, July 22, 2026
Time 03:40 PM EDT
TV ESPN Unlmtd
The Athletics and Arizona Diamondbacks meet Wednesday in MLB action at Chase Field. Here’s an Athletics vs Arizona Diamondbacks Prediction. This article will include an Athletics vs Arizona Diamondbacks Pick.

Athletics Betting Preview


The Athletics are 43-58 on the year and play the Twins and Red Sox next. The Athletics are batting .247 on the season, have a .324 OBP, and have a .407 slugging percentage. The Athletics’ pitching staff has a 5.29 ERA and a 1.48 WHIP. Shea Langeliers leads the Athletics with 96 hits and 51 RBI, while Nick Kurtz and Tyler Soderstrom have combined for 168 hits and 113 RBI.

Gage Jump gets the ball for the Athletics, and he is 3-5 with a 3.78 ERA and 56 strikeouts this season. This will be Jump’s first career game against the Arizona Diamondbacks.

Arizona Diamondbacks Betting Preview


The Arizona Diamondbacks are 52-49 on the year and play the Cardinals and Nationals next. The Arizona Diamondbacks are batting .238 on the season, have a .308 OBP, and have a .386 slugging percentage. The Arizona Diamondbacks’ pitching staff has a 4.21 ERA and a 1.28 WHIP. Ketel Marte leads the Arizona Diamondbacks with 100 hits and 58 RBI, while Corbin Carroll and Geraldo Perdomo have combined for 170 hits and 83 RBI.

Merrill Kelly gets the ball for the Arizona Diamondbacks, and he is 7-8 with a 5.20 ERA and 62 strikeouts this season. Kelly is 2-1 with a 3.93 ERA and 18 strikeouts in his career against the Athletics.

Why the Arizona Diamondbacks will win

Why the Athletics will win

Total Runs Facts

Arizona Diamondbacks Player Prop Facts

Athletics Player Prop Facts

Matchup/League Facts

Athletics vs Arizona Diamondbacks Prediction


I’m not thrilled to get behind Kelly, and his 5.20 ERA and 1.49 WHIP, but the Diamondbacks are playing the better baseball, and they’re at home with the quick turnaround. The A’s are a talented lineup, but they’ve also had issues producing on a consistent level, so it might not even matter. Also, Jump is still a rookie with just 52.1 innings under his belt. I’ll side with the Diamondbacks and the cheap price at home.

Randy Chambers's Pick: Arizona Diamondbacks

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