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Astros vs Reds Prediction 5/10/2026 Today’s MLB Picks

Cincinnati Reds shortstop Elly de la Cruz (44) tosses the ball to second baseman Matt McLain to start a double play on a ground ball off the bat of Houston Astros designated hitter Yordan Alvarez (44) in the third inning of the MLB Interleague game between the Cincinnati Reds and the Houston Astros at Great American Ball Park in downtown Cincinnati on Friday, May 8, 2026.

Cincinnati Reds shortstop Elly de la Cruz (44) tosses the ball to second baseman Matt McLain to start a double play on a ground ball off the bat of Houston Astros designated hitter Yordan Alvarez (44) in the third inning of the MLB Interleague game between the Cincinnati Reds and the Houston Astros at Great American Ball Park in downtown Cincinnati on Friday, May 8, 2026.

MATCHUP Houston Astros Cincinnati Reds
Team Records 16-24 21-19
Spread +1.5 -186 -1.5 153
Moneyline +104 -126
Total Over 9 (100) Under 9 (-120)
Where Great American Ball Park, Cincinnati, Ohio
When Sunday, May 10, 2026
Time 01:40 PM EDT
TV MLB.TV

In this article we will formulate an Astros vs Reds prediction for this MLB game on Sunday, May 10th at Great American Ball Park in Cincinnati, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Houston Astros Betting Preview

The Houston Astros are 16-24 this season after they split the first two games in this series by scores of 10-0 and 1-3. In game two, Houston led 1-0 in the fifth inning, but they couldn’t find anymore offense in the loss. The Astros recorded four hits and they committed two errors in the game, while they were led by Shewmake, who went 1-3 with one home run and one RBI. Arrighetti allowed five hits and one earned run over 5.2 innings for the loss, while Okert threw one scoreless inning in relief. Prior to this series, Houston lost two out of three against the Dodgers, but did win two out of three against the Red Sox before that. 

This season, Houston has a 5.56 ERA with a 1.59 WHIP and a .263 opponent batting average, while they have scored 196 runs with a .261 batting average and a .337 on base percentage. Yordan Alvarez has led the Astros with 13 home runs and 29 RBIs, while Christian Walker has added nine home runs and 27 RBIs. The projected starting pitcher for Houston is Kai-Wei Teng, who is 1-2 with a 2.35 ERA and a 0.96 WHIP over 23.0 innings pitched this season. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 21-19 this year after they won game two by a score of 3-1 on Saturday afternoon. Cincinnati scored all three of their runs in the fifth inning, which was enough to get the low scoring win. The Reds recorded five hits in the game and they were led by McLain, who went 1-3 with two RBIs. Burns allowed four hits and one earned run over 6.0 innings for the win, while Johnson picked up the save. Prior to this series, Cincinnati lost all four against the Cubs and all three against the Pirates. 

This season, Cincinnati has a 4.63 ERA with a 1.49 WHIP and a .254 opponent batting average, while they have scored 159 runs with a .218 batting average and a .303 on base percentage. Sal Stewart has led the Reds with 10 home runs and 30 RBIs, while Elly De La Cruz has added 10 home runs and 29 RBIs. The projected starting pitcher for Cincinnati is Andrew Abbott, who is 1-2 with a 5.13 ERA and a 1.64 WHIP over 40.1 innings pitched this year. 

Why the Cincinnati Reds will win

Why the Houston Astros will win

Total Runs Facts

Cincinnati Reds Player Prop Facts

Houston Astros Player Prop Facts

Astros vs Reds Prediction 

Cincinnati finally snapped their losing streak with a win on Saturday, but they have allowed 7+ runs in three of their last four games. The Reds are 11-9 at home this year, while the Astros are 7-14 on the road. Houston has alternated wins and losses over their last five games and they have scored three runs or fewer in four of their last five. The Astros are starting Teng, who will only pitch a couple of innings, while Abbott has allowed two earned runs in his last 11.2 innings. Take the Reds to get another win here.

David Racey's Pick: Reds ML

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