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Arizona Diamondbacks vs San Francisco Giants Prediction 5/25/2026 Today’s MLB Picks

May 24, 2026; Phoenix, Arizona, USA; Fans welcome Arizona Diamondbacks right fielder Tommy Troy (9) Major League Debut against the Colorado Rockies after the game at Chase Field. Mandatory Credit: Anna Carrington-Imagn Images

May 24, 2026; Phoenix, Arizona, USA; Fans welcome Arizona Diamondbacks right fielder Tommy Troy (9) Major League Debut against the Colorado Rockies after the game at Chase Field. Mandatory Credit: Anna Carrington-Imagn Images

MATCHUP Arizona Diamondbacks San Francisco Giants
Team Records 28-24 22-31
Spread +1.5 -185 -1.5 152
Moneyline +114 -137
Total Over 7.5 (-114) Under 7.5 (-105)
Where Oracle Park, San Francisco, California
When Monday, May 25, 2026
Time 05:05 PM EDT
TV MLB.TV
The Arizona Diamondbacks and San Francisco Giants meet Monday in MLB action at Comerica Park. Here’s an Arizona Diamondbacks vs. San Francisco Giants Prediction. This article will include an Arizona Diamondbacks vs. San Francisco Giants Pick.

Arizona Diamondbacks Betting Preview


The Arizona Diamondbacks are 28-24 on the year and play the Mariners and Dodgers next. The Arizona Diamondbacks are batting. 248 on the season, have a .313 OBP, and have a .404 slugging percentage. The Arizona Diamondbacks’ pitching staff has a 4.08 ERA and a 1.25 WHIP. Ildemaro Vargas leads the Arizona Diamondbacks with 55 hits and 32 RBI while Ketel Marte and Corbin Carroll have combined for 104 hits and 55 RBI.

Merrill Kelly gets the ball for the Arizona Diamondbacks, and he is 4-3 with a 5.71 ERA and 27 strikeouts this season. Kelly is 9-5 with a 3.30 ERA and 110 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview


The San Francisco Giants are 22-31 on the year and play the Brewers and Rockies next. The San Francisco Giants are batting. 247 on the season, have a .295 OBP, and have a .387 slugging percentage. The San Francisco Giants’ pitching staff has a 4.22 ERA and a 1.34 WHIP. Luis Arraez leads the San Francisco Giants with 63 hits and 18 RBI while Rafael Devers and Casey Schmitt have combined for 100 hits and 54 RBI.

Landen Roupp gets the ball for the San Francisco Giants, and he is 5-4 with a 3.27 ERA and 61 strikeouts this season. Roupp is 0-0 with a 3.45 ERA and 13 strikeouts in his career against the Arizona Diamondbacks.

Why the San Francisco Giants will win

Why the Arizona Diamondbacks will win

Total Runs Facts

San Francisco Giants Player Prop Facts

Arizona Diamondbacks Player Prop Facts

Matchup/League Facts

Arizona Diamondbacks vs San Francisco Giants Prediction


The Giants have the edge with Roupp on the mound, but the team overall has had issues stringing wins together. Even with the lesser pitcher in Kelly who has a 5.71 ERA and 1.51 WHIP, the Diamondbacks are coming off a hell of a week and it forces me to look toward the plus money. Also for what it’s worth Kelly has been better this month, allowing 23 hits and 11 runs in his last 26.1 innings. We’re getitng the more favorable price with the team in better form. Give it to me.

Randy Chambers's Pick: Arizona Diamondbacks

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