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Arizona Diamondbacks vs Houston Astros Prediction 9/4/2026 Today’s MLB Picks

Aug 9, 2026; San Diego, California, USA; Houston Astros starting pitcher Cristian Javier (53) throws a pitch during the first inning against the San Diego Padres at Petco Park. Mandatory Credit: David Frerker-Imagn Images

Aug 9, 2026; San Diego, California, USA; Houston Astros starting pitcher Cristian Javier (53) throws a pitch during the first inning against the San Diego Padres at Petco Park. Mandatory Credit: David Frerker-Imagn Images

MATCHUP Arizona Diamondbacks Houston Astros
Team Records 74-67 72-69
Spread +1.5 -188 -1.5 155
Moneyline +112 -135
Total Over 9 (100) Under 9 (-120)
Where Daikin Park, Houston, Texas
When Friday, September 4, 2026
Time 08:10 PM EDT
TV MLB.TV
In this article, we will formulate a Diamondbacks vs Astros Prediction for this MLB matchup on Friday, September 4th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Houston Astros Preview


The Houston Astros have a 72-69 record this season and are sitting in the 1st place of the AL West. They have a 36-36 home record and are coming off a 6-2 home win against the White Sox. They will face the Phillies and the Rays next.

The Houston Astros have a .240 batting average this season, .315 OBP, and .408 slugging percentage. Houston’s pitching staff has a 4.56 ERA and 1.36 WHIP. Yordan Alvarez is the Astros’ best hitter with a .316 batting average, while leading the team in RBI with 94, adding a team-high 37 home runs.

Cristian Javier (R) is the projected starting pitcher for the Astros, with a 1-5 record, 6.45 ERA, and 1.63 WHIP.

Arizona Diamondbacks Preview


The Arizona Diamondbacks have a 74-67 record this season and are sitting in the 2nd place of the NL West. They have a 33-36 road record and are coming off a 1-0 home win against the Phillies. They will face the Royals and the Rangers next.

The Arizona Diamondbacks have a .243 batting average this season, .315 OBP, and .395 slugging percentage. Arizona’s pitching staff has a 4.16 ERA and 1.29 WHIP. Gabriel Moreno is the Diamondbacks’ best hitter with a .298 batting average. Ketel Marte leads the team in RBI with 67, while Nolan Arenado adds a team-high 21 home runs.

Merrill Kelly (R) is the projected starting pitcher for the Diamondbacks, with a 9-12 record, 5.08 ERA, and 1.48 WHIP.

Arizona Diamondbacks @ Houston Astros Betting Trends: September 4, 2026


Why the Houston Astros will win

Why the Arizona Diamondbacks will win

Total Runs Facts

Houston Astros Player Prop Facts

Arizona Diamondbacks Player Prop Facts

Matchup/League Facts

Diamondbacks vs Astros Prediction


The Astros are 8-1 in their last 9 meetings against the Diamondbacks and have won two of their last three meetings in Houston.

In this Diamondbacks vs Astros Prediction, the Astros are coming as -125 home favorites. I don’t like the pitching in this game, as both starters have a combined 11.53 ERA and almost 1.50+ WHIP. Kelly has given up 15 runs in three of his last four starts and Javier 3+ runs in four of his last five starts. Both bullpens have a 4+ ERA this season and even though both offenses have been struggling lately, everything indicates that they will bounce back today. Take the over 8.5 runs in this one.

Nikos Lagouretos's Pick: Over 8.5

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