Syracuse vs Virginia Prediction 10/10/2026 Today’s College Football Picks
Chris Ruffolo
Oct 3, 2026; East Hartford, Connecticut, USA; Syracuse Orange wide receiver Darius Johnson (6) runs with the ball against Connecticut Huskies defensive back Renick Dorilas (6) during the second half at Pratt & Whitney Stadium at Rentschler Field. Mandatory Credit: Gregory Fisher-Imagn Images
MATCHUP
Syracuse Orange
Virginia Cavaliers
Team Records
2-2
3-2
Spread
+11.5 -110
-11.5 -110
Moneyline
+340
-440
Total
Over 49.5 (-110)
Under 49.5 (-110)
Where
Scott Stadium, Charlottesville, VA
When
Saturday, October 10, 2026
Time
07:30 PM EDT
TV
ACC Network
The Syracuse Orange and the Virginia Cavaliers meet in week 6 college football action from the Scott Stadium on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Syracuse Orange vs. Virginia Cavaliers Prediction.
Syracuse Orange Recap
The Syracuse Orange come into this game looking to build on their 42-41 win over UConn last time out to sit at 2-2 this season. After this game, Syracuse will head home for a game against Louisville.
Orange Snap Two-Game Slide
Steve Angeli has thrown for 731 yards, 4 touchdowns and 5 interceptions on 54.8% passing while Tylik Hill leads Syracuse in rushing with 287 yards and a touchdown through 5 games this season. Shavane Anderson Jr. sits behind Hill on the ground with 146 yards and 3 touchdowns. Umari Hatcher leads the Orange in receiving with 434 yards and 29 catches along with 5 touchdowns, while Justus Ross-Simmons trails with 161 yards and 10 catches. On defense, Chris D’Appolonia has a team-high 26 tackles while Syracuse’s defense as a whole has combined for 11 sacks and 2 interceptions through 5 games this season.
Virginia Cavaliers Recap
The Virginia Cavaliers come into this game looking to bounce back from a 38-7 loss at the hands of Florida State last time out to sit at 3-2 this season. After this game, Virginia will head on the road for a game against SMU.
Cavaliers Alternate Wins & Losses In 4 Straight
Beau Pribula has thrown for 961 yards, 12 touchdowns and an interception on 67.8% passing while Jekail Middlebrook leads Virginia in rushing with 242 yards and a touchdown through 5 games this season. Xavier Brown sits behind Middlebrook on the ground with 166 yards and 2 touchdowns. Kameron Courtney leads the Cavaliers in receiving with 166 yards and 15 catches along with 2 touchdowns, while Rico Flores Jr. trails with 152 yards and 11 catches. On defense, Jacobie Henderson has a team-high 26 tackles while Virginia’s defense as a whole has combined for 11 sacks and 8 interceptions through 5 games this season.
Syracuse Orange @ Virginia Cavaliers Betting Trends: Week 6
Why the Virginia Cavaliers will win
Syracuse has lost each of its last nine games against conference opponents.
Virginia has won nine of its last 10 games at Scott Stadium.
Virginia has covered the spread in each of its last four games at Scott Stadium.
Syracuse has failed to cover the spread in each of its last four games in October.
Virginia has won the first quarter in 10 of its last 11 games against non-AP-ranked teams.
Syracuse has lost the first half in each of its last 13 October games as an underdog against non-AP-ranked teams.
Why the Syracuse Orange will win
Syracuse has won three of its last four games as an underdog against teams from Virginia.
Virginia has failed to cover the spread in each of its last four October games as a favorite.
Syracuse has covered the spread in three of its last four games as an underdog against teams from Virginia.
Virginia has lost the first half in four of its last five October games as a favorite.
Total Points Facts
Each of Virginia’s last seven October games against non-AP-ranked teams have gone UNDER the total points line.
Each of Syracuse’s last five games as an underdog against non-AP-ranked teams have gone UNDER the total points line.
Virginia Cavaliers Player Prop Facts
Heading into Week 6, Brandyn Hillman ranks T2nd amongst FBS players for interceptions (3) this season.
Syracuse Orange Player Prop Facts
Heading into Week 6, Umari Hatcher ranks T11th amongst FBS players for receiving touchdowns (5) this season.
Matchup/League Facts
Virginia ranks 3rd among FBS teams for sacks this season (20.0).
Virginia ranks T4th among FBS teams for average point differential in first quarters this season (+10.4).
Syracuse ranks 5th among FBS teams for Q2 points per game this season (16.8).
Syracuse ranks 10th among FBS teams for time of possession per game this season (33:51).
Syracuse Orange vs. Virginia Cavaliers Prediction
I’m on the under here. This for me is just another game on Saturday’s card that I think will be affected by weather and even if it wasn’t, these are two teams I don’t trust offensively, especially at the QB position. and I think this is a spot where it’s just a lot of mucking around between the 20s in a low-scoring game. Give me the under.
