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South Carolina vs Alabama Prediction 9/26/2026 Today’s College Football Picks

Sep 19, 2026; Tuscaloosa, AL, USA;  Alabama wide receiver Ryan Coleman-Williams (1) runs for a long touchdown at Bryant-Denny Stadium. Alabama defeated Florida State 50-36. Mandatory Credit: Gary Cosby Jr.-Tuscaloosa News

Sep 19, 2026; Tuscaloosa, AL, USA; Alabama wide receiver Ryan Coleman-Williams (1) runs for a long touchdown at Bryant-Denny Stadium. Alabama defeated Florida State 50-36. Mandatory Credit: Gary Cosby Jr.-Tuscaloosa News

MATCHUP South Carolina Gamecocks Alabama Crimson Tide
Team Records 2-1 3-0
Spread +12.5 -110 -12.5 -110
Moneyline +370 -485
Total Over 54.5 (-108) Under 54.5 (-112)
Where Bryant-Denny Stadium, Tuscaloosa, AL
When Saturday, September 26, 2026
Time 07:00 PM EDT
TV ESPN
The South Carolina Gamecocks and Alabama Crimson Tide meet Saturday in week 4 college football action at Bryant-Denny Stadium. Here’s a South Carolina vs. Alabama Prediction. This article will include a South Carolina vs. Alabama Pick.

South Carolina Gamecocks Betting Preview


The South Carolina Gamecocks beat Towson, lost to Mississippi State, and will play Kentucky next. The South Carolina Gamecocks have split their last 6 games. LaNorris Sellers is completing 62.8 percent of his passes for 648 yards, 5 touchdowns, and 3 interceptions. Nyck Harbor and Donovan Murph have combined for 263 receiving yards and 2 touchdowns, while Matt Fuller has 8 receptions.

The South Carolina Gamecocks’ ground game averages 277.3 yards per contest, and Matt Fuller leads with 272 yards and 3 touchdowns. On defense, South Carolina allows 16.7 points and 258.3 yards per game. Justin Okoronkwo leads the South Carolina Gamecocks with 19 tackles, Anthony Addison has 2 sacks, and Peyton Williams has 1 interception.

Alabama Crimson Tide Betting Preview


The Alabama Crimson Tide beat Kentucky and Florida State, and they play Mississippi State next. Alabama looks for its ninth 4-0 start in the last 11 years. Keelon Russell is completing 68.7 percent of his passes for 764 yards, 4 touchdowns, and 2 interceptions. Ryan Coleman-Williams and Lotzeir Brooks have combined for 413 receiving yards and 1 touchdown, while Rico Scott has 9 receptions.

The Alabama Crimson Tide ground game is averaging 209.7 yards per contest, and Daniel Hill leads the way with 210 yards and 3 touchdowns. Defensively, Alabama is allowing 21 points and 280.7 yards per game. Caleb Woodson leads the Alabama Crimson Tide with 18 tackles, Devan Thompkins has 3 sacks, and Red Morgan has 1 interception.

Why the Alabama Crimson Tide will win

Why the South Carolina Gamecocks will win

Total Points Facts

Alabama Crimson Tide Player Prop Facts

South Carolina Gamecocks Player Prop Facts

Matchup/League Facts

South Carolina vs Alabama Prediction


I want to believe in South Carolina and Sellers, but coming up small against Mississippi State at home isn’t a good sign. South Carolina has a history of tripping over itself when it’s time to show and prove. We’ve seen back-to-back weeks where Alabama pulls away in a quarter or two, and it’s showing scary potential. Alabama blew the doors off Kentucky in the second half and survived rain delays to give FSU the business. One slip-up, or two, and South Carolina will find itself down big. I’ll lay the points with the Tide.

Randy Chambers's Pick: Alabama -12.5

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