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Notre Dame vs Purdue Prediction 9/26/2026 Today’s College Football Picks

Sep 19, 2026; Pasadena, California, USA; Purdue Boilermakers running back Fame Ijeboi (2) carries the ball against UCLA Bruins linebacker Scott Taylor (20), defensive back Malik Hartford (12) and defensive back Ty Lee (22) in the first half at the Rose Bowl. Mandatory Credit: Kirby Lee-Imagn Images

Sep 19, 2026; Pasadena, California, USA; Purdue Boilermakers running back Fame Ijeboi (2) carries the ball against UCLA Bruins linebacker Scott Taylor (20), defensive back Malik Hartford (12) and defensive back Ty Lee (22) in the first half at the Rose Bowl. Mandatory Credit: Kirby Lee-Imagn Images

MATCHUP Notre Dame Fighting Irish Purdue Boilermakers
Team Records 3-0 1-2
Spread -27.5 -118 +27.5 -102
Moneyline -4500 +1700
Total Over 58.5 (-105) Under 58.5 (-115)
Where Ross-Ade Stadium, West Lafayette, IN
When Saturday, September 26, 2026
Time 02:00 PM EDT
TV Peacock
The Notre Dame Fighting Irish and Purdue Boilermakers meet Saturday in week 4 college football action at Ross-Ade Stadium. Here’s a Notre Dame vs. Purdue Prediction. This article will include a Notre Dame vs. Purdue Pick.

Notre Dame Fighting Irish Betting Preview


The Notre Dame Fighting Irish beat Michigan State and Rice, and play North Carolina next. The Notre Dame Fighting Irish have won 13 straight games. CJ Carr is completing 72.6 percent of his passes for 726 yards, 6 touchdowns, and 0 interceptions. Jordan Faison and Micah Gilbert have combined for 424 receiving yards and 3 touchdowns, while Nolan James Jr. has 7 receptions.

The Notre Dame Fighting Irish ground game is averaging 130 yards per contest, and Nolan James Jr. leads the way with 169 yards and 3 touchdowns. Defensively, Notre Dame is allowing 7.7 points and 193 yards per game. Drayk Bowen leads the Notre Dame Fighting Irish with 19 tackles, Boubacar Traore has 2 sacks, and DJ McKinney has 1 interception.

Purdue Boilermakers Betting Preview


The Purdue Boilermakers lost to Wake Forest and UCLA, and they play Illinois next. The Purdue Boilermakers have lost 12 of their last 14 games. Ryan Browne is completing 73.3 percent of his passes for 1,024 yards, 7 touchdowns, and 1 interception. Asaad Waseem and Xavier Townsend have combined for 588 receiving yards and 3 touchdowns, while Chauncey Magwood has 8 receptions.

The Purdue Boilermakers’ ground game is averaging 183 yards per contest, and Fame Ijeboi leads the way with 248 yards and 6 touchdowns. Defensively, Purdue is allowing 54.5 points and 670 yards per game. John Slaughter leads the Purdue Boilermakers with 22 tackles, Ian Jeffries has 1 sack, and Don Saunders has 1 interception.

Why the Purdue Boilermakers will win

Why the Notre Dame Fighting Irish will win

Total Points Facts

Purdue Boilermakers Player Prop Facts

Notre Dame Fighting Irish Player Prop Facts

Matchup/League Facts

Notre Dame vs Purdue Prediction


Notre Dame has the ability to blow the doors off, but this is a ton of points for a road spot. Also, Purdue deserves some credit as it nearly beat Wake Forest and then went into UCLA and dropped 38 points. Now Purdue hasn’t played a lot of defense, but the fight has improved, and there are sparks of successful offense. Purdue is already a better team than it’s been in past seasons. If the trend upward continues, the Boilermakers can cash our ticket. Give me the four free touchdowns.

Randy Chambers's Pick: Purdue +27.5

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