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Indiana Fever vs Las Vegas Aces Prediction 9/21/2025 Today’s WNBA Picks

Sep 18, 2025; Las Vegas, Nevada, USA; Las Vegas Aces center A'ja Wilson (22) reacts to a play against the Seattle Storm in the third quarter during game three of round one for the 2025 WNBA Playoffs at Michelob Ultra Arena. Mandatory Credit: Candice Ward-Imagn Images

Sep 18, 2025; Las Vegas, Nevada, USA; Las Vegas Aces center A'ja Wilson (22) reacts to a play against the Seattle Storm in the third quarter during game three of round one for the 2025 WNBA Playoffs at Michelob Ultra Arena. Mandatory Credit: Candice Ward-Imagn Images

Indiana (24-20) vs Las Vegas (30-14)

September 21, 2025 at 03:00 PM EDT

The Line: Betting Odds: Las Vegas -9 — Over/Under: +164.5

(Get latest betting odds)

The Indiana Fever and the Las Vegas Aces meet Sunday in WNBA semi-final playoff action from the T-Mobile Arena. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Indiana Fever vs. Las Vegas Aces prediction.

Matchup History

The Indiana Fever won back-to-back meetings between these two teams including an 80-70 win on July 24th, 2025, to give Indiana the win in the season series. The home team won all three meetings between these two teams this season. 

Indiana Fever Recap

The Indiana Fever come into this game off of their series win over the Atlanta Dream with an 87-85 win over Atlanta in their series-deciding game three last time out.

Fever Looking To Spring Another Upset

Kelsey Mitchell leads the Fever in scoring with 20.3 PPG along with 3.4 APG while Caitlin Clark has 16.5 PPG with 5 RPG and a team-high 8.8 APG to lead the Fever in assists, but is out for the rest of the season with an injury. Aliyah Boston has 15.4 PPG with a team-high 8.3 RPG and 3.6 APG to lead the Fever in rebounding and Natasha Howard has 11.3 PPG with 6.7 RPG. Odyssey Sims has 10.6 PPG and 4.1 APG in 8 games played so far to cap off the scoring in double figures for the Fever so far this season. Lexie Hull has added 7 PPG with 4.4 RPG. Sophie Cunningham also has 8.6 PPG with 3.5 RPG as well on the year. 

Las Vegas Aces Recap

The Las Vegas Aces come into the semifinals after taking down the Seattle Storm with a 74-73 win in the winner take all game three.

Aces Looking To Reclaim WNBA Throne

A’Ja Wilson leads the Aces across the board with 21.5 PPG along with 9.1 RPG to go along with 3.3 APG, 2.3 BPG and 1.7 SPG. Jackie Young has 16.6 PPG with 4.1 RPG and 4.5 APG as well this season. Chelsea Gray has chipped in 11 PPG with 4.1 RPG and 4.5 APG and Jewell Loyd’s added 11.4 PPG with 3.7 RPG to round out the group of double-digit scorers for Las Vegas so far this season.

Indiana Fever @ Las Vegas Aces Betting Trends: September 21, 2025

Why the Las Vegas Aces will win

  • The Aces have won each of their last 12 home games.
  • The Fever have lost 15 of their last 16 games against Aces teams that held a winning record.
  • The Aces have covered the spread in each of their last six Sunday day games.
  • The Fever have failed to cover the spread in 17 of their last 20 games against Western Conference opponents after winning as underdogs.

Why the Indiana Fever will win

  • The Fever have won three of their last four games as underdogs.
  • The Aces have lost six of their last seven day games against Eastern Conference opponents that held a winning record.
  • The Fever have covered the spread in each of their last six day games against Western Conference opponents that held a winning record.
  • The Aces have failed to cover the spread in 10 of their last 12 Semi-Finals games as favorites.

Total Points Facts

  • Each of the last six games between the Aces and Fever have gone UNDER the total points line.
  • Each of the Fever’s last four games against Western Conference opponents have gone UNDER the total points line.

Las Vegas Aces Player Facts

  • A’ja Wilson ranks 1st amongst qualified players for points per game (23.4) this season.
  • Chelsea Gray leads all Las Vegas Aces players for assists per 36 minutes (6.3) this season.

Indiana Fever Player Facts

  • Kelsey Mitchell ranks 1st amongst qualified players in the Eastern Conference for points per game (20.2) this season.
  • Aliyah Boston ranks 1st amongst qualified Centers for assists per game (3.7) this season.

Matchup/League Facts

  • The Las Vegas Aces rank 1st for opponent blocks per game this season (2.6).
  • The Las Vegas Aces rank 12th for opponent free throw percentage this season (81.5%).
  • The Indiana Fever have recorded the largest comeback win after HT this season – trailed by 19 points @ Connecticut Sun on August 17.
  • The Indiana Fever have scored 90+ points in 10 home games this season – most in the WNBA.

Indiana Fever vs. Las Vegas Aces Prediction

I’m on the Aces here. I get that the Fever are going to be an attractive underdog given what they just did against the Dream. However, the Aces are still arguably the hottest team in the WNBA right now, and I think that the Fever are just up against it in this matchup. Until I have a reason to think the Aces would fall short here, I’m rolling with Las Vegas in this one.

Chris Ruffolo's Pick: Las Vegas -9

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