Arizona Cardinals (0-0) at San Francisco 49ers (0-0)

Sunday, September 13, 2020 at 4:25 pm

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*4 Star Play on Arizona* Week one is a great time to take divisional underdogs in the NFL. Divisional underdogs are 38-16-1 ATS in their last 55 in week one in the NFL. Also, teams who won six games or less in the previous season and are underdogs on the road in week one are 49-23 ATS in their last 72 games. 

Arizona has upgraded some on defense, and the addition of Hopkins at wide receiver makes this team far more dangerous offensively. In year two of Kingsbury's offense with Murray at the helm, we should see a big jump in production.

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The 49ers are banged up to start the season. San Francisco will either be without Deebo Samuel or he'll be playing at far less than 100% here. 

The 49ers defense should regress a bit in the secondary. Sherman isn't getting any younger and the guys around him aren't quite as good. 

Arizona played San Francisco very tough last year, and the Cardinals are better than they were a season ago.

Take Arizona. 

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Kyle’s Pick Arizona Cardinals: +7 -120

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