St. Louis Blues vs Buffalo Sabres Prediction 11/6/2025 Today’s NHL Picks
Chris Ruffolo
Nov 1, 2025; Buffalo, New York, USA; Buffalo Sabres center Tage Thompson (72) looks to make a pass during the third period against the Washington Capitals at KeyBank Center. Mandatory Credit: Timothy T. Ludwig-Imagn Images
MATCHUP
Blues St. Louis
Sabres Buffalo
Team Records
4-8-2
5-4-4
Spread
+1.5 -230
-1.5 190
Moneyline
+114
-135
Total
Over 6.5 (100)
Under 6.5 (-120)
Where
KeyBank Center, Buffalo, NY
When
Thursday, November 6, 2025
Time
07:00 PM EST
TV
ESPN+
The St. Louis Blues and the Buffalo Sabres meet Thursday in NHL action from the KeyBank Center. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Blues vs. Buffalo Sabres prediction.
St. Louis Blues Recap
The St. Louis Blues come into this game looking to bounce back from a 6-1 loss at the hands of the Washington Capitals to sit at 4-8-2 this season. After this game, St. Louis will head home for a game against the Seattle Kraken.
Blues Drop 8 Of Last 9
Pius Suter leads the Blues with 9 points including 5 goals and 4 assists while Jimmy Snuggerud and Jordan Kyrou each have 8 points with 4 goals and 4 assists apiece and Robert Thomas added 8 points with 2 goals and 6 assists. Jake Neighbours has chipped in 7 points with a team-high 6 goals while Dylan Holloway, Justin Faulk, Pavel Buchnevich and Brayden Schenn each have 6 points with 2 goals and 4 assists and Colton Parayko has 6 assists. Cam Fowler and Oskar Sundqvist each have 5 assists and Cam Fowler has 5 points with a goal and 4 assists. Jordan Binnington has gone 3-5-2 with a 3.08 GAA and an .859 save percentage in goal for St. Louis while Joel Hofer is 1-3 with a 5.16 GAA and an .829 save percentage so far this season.
Buffalo Sabres Recap
The Buffalo Sabres come into this game looking to bounce back from a 2-1 OT loss at the hands of Utah last time out to sit at 5-4-4 this season. After this game, Buffalo will head on the road for a game against the Carolina Hurricanes.
Sabres Drop 4 Of Last 5
Alex Tuch leads Buffalo with 12 points including 5 goals and 7 assists while Rasmus Dahlin has 9 points with a team-high 8 assists and Tage Thompson has 10 points with 5 goals and 5 assists. Zach Benson’s added 8 assists and Josh Doan has 9 points with 4 goals and 5 assists. Jason Zucker has 7 points with 4 goals and 3 assists while Jack Quinn and Ryan McLeod each have 7 points with 3 goals and 4 assists. Alex Lyon has gone 3-4-3 with a 2.81 GAA and a .915 save percentage in goal for Buffalo while Colten Ellis is 1-0 with a 2.00 GAA and a .935 save percentage so far this season. Ukko-Pekka Luukkonen has gone 1-0-1 with a 3.34 GAA and an .877 save percentage up to this point in the year.
St. Louis Blues @ Buffalo Sabres Betting Trends: November 6, 2025
Why the Buffalo Sabres will win
The Blues have lost each of their last six road games on the second leg of a back-to-back.
The home team has won eight of the Sabres’ last 10 games.
The Blues have failed to cover the puck line in each of their last three games against Atlantic Division opponents.
The Sabres have covered the puck line in six of their last eight home games against Central Division opponents.
The Blues have lost the second period in each of their last five road games against Eastern Conference opponents when trailing after the first period.
Why the St. Louis Blues will win
The underdogs have won nine of the Blues’ last 12 games.
The Sabres have lost four of their last six games as home favorites after coming off overtime.
The underdogs have covered the puck line in each of the Sabres’ last six games.
The Sabres have failed to cover the puck line in six of their last seven games as favorites after coming off overtime.
The Sabres have lost the second period in each of their last nine home games against Western Conference opponents when leading after the first period.
Total Goals Facts
Each of the last nine night games between the Blues and Sabres have gone OVER the total goals line.
Seven of the Blues’ last eight road games have gone OVER the total goals line.
The ‘Over 2.5 Goals Period 1’ market has hit in four of the last five games between the Blues and Sabres.
The ‘Over 1.5 Goals Period 1′ market has hit in six of the Blues’ last seven games against Atlantic Division opponents.
Buffalo Sabres Player Prop Facts
Alex Tuch has scored a goal in seven of the Sabres’ last eight games as favorites.
Alex Tuch has recorded at least one point in each of the Sabres’ last eight games as favorites.
Jack Quinn has recorded an assist in each of his last five appearances with the Sabres as home favorites against Central Division opponents.
St. Louis Blues Player Prop Facts
Robert Thomas has recorded at least one assist in each of his last five appearances against Atlantic Division opponents.
Jordan Kyrou has scored a goal in each of the Blues’ last four games against Atlantic Division opponents.
Brayden Schenn has recorded at least one point in each of the Blues’ last six games against the Sabres.
Matchup/League Facts
The Buffalo Sabres rank 1st in the league in penalty kill percentage this season (90.91%).
The Buffalo Sabres rank T1st in the league for power play goals against this season (4).
The St. Louis Blues rank 32nd in the league for goals against per game this season (4.14).
The St. Louis Blues rank 30th in the league in penalty kill percentage this season (67.57%).
St. Louis Blues vs. Buffalo Sabres Prediction
I’m on the Sabres here. I get the case to be made for St. Louis as Buffalo hasn’t been a team I have blindly backed for much of the year, but the Blues right now for me are an auto-fade team as this team has constantly disappointed for much of the season to this point. The Sabres are still not the best team ever, but they’re good enough, especially at home, to get the job done here and I think Buffalo gets the win in this one. Give me Buffalo.
