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Philadelphia Flyers vs Buffalo Sabres Prediction 10/21/2026 Today’s NHL Picks

Jan 14, 2026; Buffalo, New York, USA;  Buffalo Sabres right wing Jack Quinn (22) skates up ice with the puck during the second period at KeyBank Center. Mandatory Credit: Timothy T. Ludwig-Imagn Images

Jan 14, 2026; Buffalo, New York, USA; Buffalo Sabres right wing Jack Quinn (22) skates up ice with the puck during the second period at KeyBank Center. Mandatory Credit: Timothy T. Ludwig-Imagn Images

Philadelphia vs Buffalo Odds and Matchup Info
MATCHUP Philadelphia Flyers Buffalo Sabres
Team Records 2-6 4-3
Spread +1.5 -162 -1.5 136
Moneyline +154 -185
Total Over 5.5 (-135) Under 5.5 (114)
Where KeyBank Center, Buffalo, NY
When Wednesday, October 21, 2026
Time 07:30 PM EDT
TV TNT

In this article, we will formulate a Wild vs Oilers Prediction for this NHL game on Wednesday, October 21st. Let’s take a look at the prediction for this NHL matchup.

Buffalo Sabres Preview

The Sabres have 10 points this season with a 4-3-2 record and a 3-2-0 home record. They are 3-6 ATS and 6-3 in over/under. They are coming off a 3-4 overtime road loss against the Canadiens and will face the Capitals and Sharks next.

Offensively, the Sabres are averaging 3.00 goals per game and are scoring 9.1% of their power play opportunities. Defensively, they are allowing 3.67 goals per game and are killing 64.5% of their opponent’s power plays.

Tage Thompson leads the Sabres with 9 points, adding a team-high 5 goals, while Owen Power leads the team in assists with 6. Ukko-Pekka Luukkonen is the starting goalie for the Sabres, and he has a 3-2-2 record, with 3.59 GAA and .860 SV%. Colten Ellis is the backup goalie and he has a 1-1-0 record, with 3.19 GAA and .864 SV%.

Philadelphia Flyers Preview

The Flyers have 7 points this season with a 2-6-3 record and a 0-4-1 road record. They are 6-5 ATS and 2-9 in over/under. They are coming off a 3-2 home win against the Avalanche and will face the Ducks and Blue Jackets next.

Offensively, the Flyers are averaging 1.55 goals per game and are scoring 12.9% of their power play opportunities. Defensively, they are allowing 3.18 goals per game and are killing 84.6% of their opponent’s power plays.

Matvei Michkov leads the Flyers with 7 points, adding a team-high 6 goals, while Trevor Zegras leads the team in assists with 5. Joseph Woll is the starting goalie for the Flyers, and he has a 1-3-2 record, with 2.64 GAA and .917 SV%. Daniel Vladar is the backup goalie and he has a 1-3-1 record, with 3.58 GAA and .889 SV%.

Philadelphia Flyers @ Buffalo Sabres Betting Trends: October 21, 2026

 

Why the Buffalo Sabres will win

Why the Philadelphia Flyers will win

Total Goals Facts

Buffalo Sabres Player Prop Facts

Philadelphia Flyers Player Prop Facts

Matchup/League Facts

Flyers vs Sabres Prediction

The Sabres are 3-1 in their last 4 meetings against the Flyers and have won their last five meetings in Buffalo.

In this Flyers vs Sabres Prediction, the Sabres are coming as -180 home favorites. I don’t trust either side in this matchup, as the Sabres have been up and down and have a terrible defense, having conceded at least four goals in five of their last six games, while the Flyers have back-to-back wins, but I don’t trust them to keep rolling. The Flyers have scored three goals in each of their last two games and the Sabres are all about the over lately, with the over hitting in their last four games and all of the last 10 head-to-head meetings between those two teams had at least 6 total goals. Take the over 6.

Nikos Lagouretos's Pick: Over 6

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