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Flyers vs Sabres Prediction 10/21/2026 Today’s NHL Picks

Jan 14, 2026; Buffalo, New York, USA;  Philadelphia Flyers goaltender Samuel Ersson (33) looks to cover up the puck during the second period against the Buffalo Sabres at KeyBank Center. Mandatory Credit: Timothy T. Ludwig-Imagn Images

Jan 14, 2026; Buffalo, New York, USA; Philadelphia Flyers goaltender Samuel Ersson (33) looks to cover up the puck during the second period against the Buffalo Sabres at KeyBank Center. Mandatory Credit: Timothy T. Ludwig-Imagn Images

Philadelphia vs Buffalo Odds and Matchup Info
MATCHUP Philadelphia Flyers Buffalo Sabres
Team Records 2-6 4-3
Spread +1.5 -162 -1.5 136
Moneyline +154 -185
Total Over 5.5 (-135) Under 5.5 (114)
Where KeyBank Center, Buffalo, NY
When Wednesday, October 21, 2026
Time 07:30 PM EDT
TV TNT

In this article we will formulate a Flyers vs Sabres prediction for this NHL game on Wednesday, October 21st at the KeyBank Center in Buffalo, New York. Let’s take a look at the prediction for this NHL matchup.

Philadelphia Flyers Betting Preview

The Philadelphia Flyers are 2-6-3 this season after they defeated the Avalanche by a score of 3-2 in their last game. Philadelphia had their lead cut to 3-2 in the third period, but they locked down on defense for the win. The Flyers were out shot by a total of 26-24, won 56.9% of the face-offs, and went 1-2 on the power play in the game. Philadelphia was led by Matvei Michkov, who had two goals, while Joseph Woll stopped 24 out of 26 shots, which was a .923 save percentage.

Prior to that win, Philadelphia defeated the Senators by a score of 3-1, but lost to the Red Wings by a score of 2-1 before that. The Flyers have scored 1.55 goals per game and they have allowed 3.18 goals against per game, while also going 12.9% on the power play and 84.6% on the penalty kill this season. Matvei Michkov has led the team with six goals and one assist, while Dan Vladar is 1-3-1 with a 3.58 goals against average and an .889 save percentage this season.

Buffalo Sabres Betting Preview

The Buffalo Sabres are 4-3-2 this year after they lost to the Canadiens in overtime by a score of 4-3 in their last game. Buffalo erased a 3-1 deficit and tied the game in the third, but allowed a goal in the first minute of OT for the loss. The Sabres were out shot by a total of 34-26, won 36.8% of the face-offs, and went 0-4 on the power play in the game. Buffalo was led by Jack Quinn, who had one goal, while UPL stopped 30 out of 34 shots in the loss.

Prior to that game, Buffalo defeated the Maple Leafs by a score of 5-4, but lost to the Canadiens by a score of 4-3 before that. The Sabres have scored 3.00 goals per game and they have allowed 3.67 goals against per game, while also going 9.1% on the power play and 64.5% on the penalty kill this season. Tage Thompson has led the team with five goals and four assists, while UPL is 3-2-2 with a 3.59 goals against average and an .860 save percentage this year.

Why the Buffalo Sabres will win

Why the Philadelphia Flyers will win

Total Goals Facts

Buffalo Sabres Player Prop Facts

Philadelphia Flyers Player Prop Facts

Matchup/League Facts

Flyers vs Sabres Prediction

Philadelphia comes into this matchup on a two game winning streak and they have allowed two regulation goals or fewer in four straight games. The Flyers are 0-4-1 on the road this year, while the Sabres are 3-2-0 at home. Buffalo has alternated wins and losses over their last five games, with each of their last three going to overtime. The Sabres have gone over 5.5 goals in four straight games, but I think it will be lower scoring with how the Flyers are playing. Take the under here.

David Racey's Pick: Under 5.5

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