Colorado Avalanche vs St. Louis Blues Prediction 4/5/25 NHL Picks

The Colorado Avalanche and St. Louis Blues meet Saturday in NHL action at the Enterprise Center. Here’s a Colorado Avalanche vs St. Louis Blues Prediction. This article will include a Colorado Avalanche vs St. Louis Blues Pick.

Colorado Avalanche Betting Preview 

The Colorado Avalanche beat the Blackhawks and Blue Jackets, and they play the Golden Knights, Canucks, and Kings next. The Avs have won 16 of their last 20 games since February 26.

The Colorado Avalanche are averaging 3.35 goals per game and are scoring on 25.1 percent of their power play opportunities. Nathn MacKinnon leads Colorado with 31 goals, Cale Maker has 60 assists, and Devon Toews has 135 shots on goal. Defensively, the Colorado Avalanche are allowing 2.77 goals per game and are killing 79.8 percent of their opponent’s power plays. Mackenzie Blackwood has allowed 72 goals on 883 shots faced, while Scott Wedgewood has given up 33 goals on 405 shots.

St. Louis Blues Betting Preview 

The St. Louis Blues beat the Penguins and Red Wings, and they play the Jets, Oilers, and Kraken next. The Blues have won 11 straight games, not losing a game since March 13. 

The St. Louis Blues are averaging 3.01 goals per game and are scoring on 21 percent of their power play opportunities. Jordan Kyrou leads St. Louis with 33 goals, Robert Thomas has 51 assists, and Dylan Holloway has 178 shots on goal. Defensively, the St. Louis Blues are allowing 2.81 goals per game and are killing 73 percent of their opponent’s power plays. Jordan Binnington has allowed 133 goals on 1,354 shots faced, and Joel Hofer has given up 72 goals on 742 shots.

Why the St. Louis Blues will win

• The Blues have won each of their last 10 games at Enterprise Center.
• The Avalanche have lost five of their last eight games as road favorites against Western Conference opponents.
• The Blues have covered the puck line in eight of their last nine games as underdogs against Western Conference opponents.
• The Avalanche have failed to cover the puck line in each of their last five night games at Enterprise Center against opponents on a winning streak.
• The Avalanche have lost the third period in four of their last five games as road favorites following a road win.

Why the Colorado Avalanche will win

• The Avalanche have won 10 of their last 11 games at Enterprise Center.
• The Blues have lost nine of their last 10 games as underdogs following an overtime win.
• The Blues have failed to cover the puck line in four of their last five games as underdogs following an overtime win.
• The Avalanche have covered the puck line in each of their last three night games against opponents on a winning streak.
• The Blues have lost the second period in five of their last six games as home underdogs following a win.

Colorado Avalanche vs St. Louis Blues Injury Report 

The Blues will be without Torey Krug, Colton Parayko, Alexandre Texier, and Dylan Holloway.

The Colorado Avalanche will be without Sean Behrens, Gabriel Landeskog, Josh Manson, and Tucker Poolman. Jonathan Drouin and Martin Necas are questionable.

Colorado Avalanche vs St. Louis Blues Prediction

The Avalanche are the better team overall and they’re starting to make that push with the playoffs around the corner. However, we’re getting the Blues at home and plus money, and that’s hard to turn down. The Blues haven’t lost a game since March 13 and one of those wins was in Colorado where they won as a +150 underdog. The Blues have won the last two games against the Avs, making bettors more than +300 profit combined. This run will come to an end eventually, but it’s impossible to turn down this price with how the Blues are playing.