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Las Vegas Raiders vs San Francisco 49ers Prediction 8/27/2026 Picks

Aug 20, 2026; Houston, Texas, USA; Las Vegas Raiders quarterback Aidan O'Connell (12) under center against the Houston Texans  in second  half at Reliant Stadium. Mandatory Credit: Thomas Shea-Imagn Images

Aug 20, 2026; Houston, Texas, USA; Las Vegas Raiders quarterback Aidan O'Connell (12) under center against the Houston Texans in second half at Reliant Stadium. Mandatory Credit: Thomas Shea-Imagn Images

MATCHUP San Francisco 49ers Las Vegas Raiders
Team Records 1-1 1-1
Spread +3.5 -112 -3.5 -108
Moneyline +144 -174
Total Over 37.5 (-108) Under 37.5 (-112)
Where Las Vegas Stadium
When Thursday, August 27, 2026
Time 08:00 PM EDT
TV ESPN Unlmtd
In this article, we will formulate a 49ers vs Raiders Prediction for this NFL Preseason Week 3 matchup on Thursday, August 27th. Let’s take a look at the prediction for this NFL matchup.

Las Vegas Raiders Preview


The Las Vegas Raiders have a 1-1 record in the preseason and are sitting in the 2nd place of the AFC West. They are coming off a 22-20 road victory over the Houston Texans, where they outgained their opponents by 400-219 yards and had 68 total plays. Las Vegas had 241 passing yards, 159 rushing yards, and 23/39 completed passes, while they won the turnover battle by 1-2. The Raiders were 4/12 on third down conversions and 3/3 in the red zone. 

Aidan O’Connell led Las Vegas with 15/24 passes and 166 passing yards. Mike Washington Jr. had a team-high 56 rushing yards, while Brandon Johnson caught 2 passes for a team-high 41 receiving yards. Defensively, Tristin McCollum led the Raiders with 7 total tackles, 6 of them solo, while Patrick Johnson had one sack.

San Francisco 49ers Preview


The San Francisco 49ers have a 1-1 record in the preseason and are sitting in the 2nd place of the NFC West. They are coming off a 41-17 road victory over the Los Angeles Chargers, where they outgained their opponents by 321-229 yards and had 72 total plays. San Francisco had 175 passing yards, 146 rushing yards, and 18/36 completed passes, while they lost the turnover battle by 2-1. The 49ers were 6/16 on third down conversions and 4/4 in the red zone.

Mac Jones led San Francisco with 6/13 passes and 89 passing yards. Sincere McCormick had a team-high 53 rushing yards and one touchdown, while KhaDarel Hodge caught 4 passes for a team-high 46 receiving yards. Defensively, Tatum Bethune led the 49ers with 6 total tackles, 3 of them solo, while Victor Dimukeje had one sack.

49ers vs Raiders Prediction


The 49ers are 4-1 in 5 meetings against the Raiders and are 1-1 in their two meetings in Las Vegas. Under is 3-1 in their last 4 meetings.

In this 49ers vs Raiders Prediction, the Raiders are coming as -2 home favorites. Both teams are coming off their first wins of the preseason in week 2 and will be looking to end the preseason on a positive note. The 49ers have been looking better so far, as they have both a better offense, scoring 27 ppg to the Raiders’ 18 and defense, allowing 18 ppg to 23.5. The 49ers have also been dominating the Raiders historically, having lost only once in their five overall meetings and they have the momentum after a big 24-point road victory in LA against the Chargers. Also, last season the Raiders were terrible at home with a 2-7 record, while the 49ers were better on the road with a 7-2 record. Take the 49ers by +2 in this one.

Nikos Lagouretos's Pick: San Francisco 49ers +2

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