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Washington Commanders vs Los Angeles Chargers Prediction 10/5/2025 Today’s NFL Picks

Sep 28, 2025; East Rutherford, New Jersey, USA; Los Angeles Chargers quarterback Justin Herbert (10) runs with the ball against the New York Giants during the third quarter at MetLife Stadium. Mandatory Credit: Brad Penner-Imagn Images

Sep 28, 2025; East Rutherford, New Jersey, USA; Los Angeles Chargers quarterback Justin Herbert (10) runs with the ball against the New York Giants during the third quarter at MetLife Stadium. Mandatory Credit: Brad Penner-Imagn Images

MATCHUP Washington Commanders Los Angeles Chargers
Team Records 3-2 3-2
Where SoFi Stadium, Inglewood, CA
When Sunday, October 5, 2025
Time 04:25 PM EDT
TV FOX

The Washington Commanders and the Los Angeles Chargers meet in week 5 NFL action from SoFi Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Washington Commanders vs. Los Angeles Chargers prediction.

Washington Commanders Recap

The Washington Commanders come into this game looking to rebound from their 34-27 loss at the hands of the Atlanta Falcons last time out to drop to 2-2 this season. After this game, the Commanders will head home for a game against the Chicago Bears.

Commanders Alternate Wins & Losses To Start Season

Jayden Daniels has thrown for 433 yards and 3 touchdowns on 59.7% passing while Marcus Mariota has thrown for 363 yards, 3 touchdowns and an INT on 64.6% passing. Jacory Croskey-Merritt has a team-high 172 rushing yards and 2 touchdowns for the Commanders on the ground while Jeremy McNichols has added 106 rushing yards and a TD. Deebo Samuel leads Washington’s receivers with 22 grabs for 204 yards and 2 touchdowns while Terry McLaurin has 149 receiving yards and Zach Ertz has 14 catches for 149 yards of his own as well as 2 TDs. On defense, Bobby Wagner has a team-high 42 total tackles in addition to 18 solo tackles and a pair of sacks while Dorance Armstrong has a team-high 3 sacks. As a unit, Washington’s group has combined for 10 sacks and an interception so far this season.

Los Angeles Chargers Recap

The Los Angeles Chargers come into this game looking to bounce back from a 21-18 loss at the hands of the New York Giants in their last game to sit at 3-1 this season. After this game, the Chargers will head on the road for a game against the Miami Dolphins.

Chargers Have Three-Game Win Streak Snapped

Justin Herbert has thrown for 1,063 yards, 7 touchdowns and 3 interceptions on 63.8% passing while Omarion Hampton leads Los Angeles in rushing with 270 rushing yards and 2 TDs this season. Quentin Johnston has 337 receiving yards and 4 touchdowns to lead the Chargers’ group while Keenan Allen has 24 catches for 231 receiving yards and 3 touchdowns and Ladd McConkey’s added 16 catches and 174 receiving yards as well. On defense, Derwin James Jr. has a team-high 34 total tackles including 22 solo tackles while Daiyan Henley has a pair of sacks and an interception. Tuli Tuipulotu has a team-high 4 sacks while the Chargers’ defensive unit as a whole has combined for 13 sacks and 3 interceptions so far this season. 

Washington Commanders @ Los Angeles Chargers Betting Trends: Week 5

Why the Los Angeles Chargers will win

Why the Washington Commanders will win

Total Points Facts

Los Angeles Chargers Player Prop Facts

Washington Commanders Player Prop Facts

Matchup/League Facts

Washington Commanders vs. Los Angeles Chargers Prediction

I’m on the Chargers here. I get the case to be made for Washington catching points here, especially if Jayden Daniels is good to go. However, the Commanders have not been the same team on the road that they’ve been at home and we’ve seen the Commanders really struggle against another solid defense in Green Bay. The Chargers had a dud against the Giants, but I think they can bounce back and get a win and cover at home in this one. Give me the Chargers.

Chris Ruffolo's Pick: Los Angeles Chargers -2.5

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