| MATCHUP | Tennessee Titans | Indianapolis Colts |
|---|---|---|
| Team Records | 0-5 | 2-3 |
| Spread | +7 -115 | -7 -105 |
| Moneyline | +270 | -340 |
| Total | Over 44.5 (-112) | Under 44.5 (-108) |
| Where | Lucas Oil Stadium, Indianapolis, IN | |
| When | Sunday, October 18, 2026 | |
| Time | 01:00 PM EDT | |
| TV | Fox | |
In this article, we will formulate a Titans vs Colts Prediction for this NFL Week 5 game on Sunday, October 18th. Let’s take a look at the prediction for this NFL matchup.
Indianapolis Colts Preview
The Indianapolis Colts have a 2-3 record this season are sitting on the 2nd place of the AFC South. They are coming off a 22-34 road loss against the Steelers and will face the Vikings, the Jaguars and the Cowboys next.
Offensively, the Colts average 24.8 points per game, ranking 11th in the NFL, while defensively, they allow 27.6 points per game, which is 27th. Indianapolis averages 293.8 total yards per game (193 passing and 100.8 rushing), while allowing 384.2 total yards per game (130.2 rushing and 254 passing).
Daniel Jones leads the Colts with 1021 passing yards with 61.4% completed passes and three touchdowns. Jonathan Taylor leads the team in rushing yards with 398, while Josh Downs has 20 receptions for a team-high 249 receiving yards. Defensively, Akeem Davis-Gaither has a team-high 44 total tackles (23 of them solo), while DeForest Buckner leads the team in sacks, with 4.
Tennessee Titans Preview
The Tennessee Titans have a 0-5 record this season are sitting on the 4th place of the AFC South. They are coming off a 3-26 home loss against the Texans and will face the Browns, the Bengals and the Jaguars next.
Offensively, the Titans average 11.6 points per game, ranking 32nd in the NFL, while defensively, they allow 21.8 points per game, which is 10th. Tennessee averages 246.4 total yards per game (163.8 passing and 82.6 rushing), while allowing 331.8 total yards per game (114 rushing and 217.8 passing).
Cam Ward leads the Titans with 896 passing yards with 63.2% completed passes and three touchdowns. Tony Pollard leads the team in rushing yards with 273, while Carnell Tate has 23 receptions for a team-high 274 receiving yards. Defensively, Anthony Hill has a team-high 47 total tackles (17 of them solo), while Jacob Martin leads the team in sacks, with 2.5.
Tennessee Titans @ Indianapolis Colts Betting Trends: Week 6
Why the Indianapolis Colts will win
- The Titans have lost each of their last 11 games against AFC South opponents.
- The Colts have won each of their last 10 home games against AFC opponents on a losing streak.
- The Colts have covered the spread in each of their last six games against the Titans.
- The Titans have failed to cover the spread in 10 of their last 11 games against AFC South opponents.
- The Titans have lost the first quarter in three of their last four road games against teams that held a losing record.
- The Titans have lost the first half in each of their last 13 road games.
- The Colts have scored the first touchdown in each of their last eight games at Lucas Oil Stadium.
Why the Tennessee Titans will win
- The Colts have lost each of their last six games without DeForest Buckner.
- The Titans have won each of their last two games as road underdogs following a Division game.
- The Titans have covered the spread in each of their last four games as underdogs following a Division game.
- The Colts have failed to cover the spread in six of their last seven home games without Andrew Ogletree.
- The Titans have scored the first touchdown in each of their last four games following a home loss.
- The Colts have lost the first quarter in four of their last five October games as favorites against AFC opponents.
- The Colts have lost the first half in four of their last five games as favorites.
Total Points Facts
- Each of the Titans’ last six games against the Colts following a home loss have gone OVER the total points line.
- Eight of the Colts’ last nine games as favorites against the Titans have gone OVER the total points line.
- Three of the last four Sunday games at Lucas Oil Stadium have gone UNDER the total points line.
Indianapolis Colts Player Prop Facts
- Nick Westbrook-Ikhine has recorded 10+ receiving yards in 12 of his last 14 appearances with his team as a favorite following a loss.
- Anthony Richardson has scored a touchdown in three of his four previous home appearances against AFC South opponents.
- Heading into Week 6, Spencer Shrader ranks 1st in the NFL in made field goals (16) this season.
Tennessee Titans Player Prop Facts
- Wan’Dale Robinson has scored a touchdown in each of his last three Sunday appearances with his team as a road underdog.
- Cam Ward has recorded 222+ passing yards in each of the Titans’ last four October road games.
- Calvin Ridley has recorded 28+ receiving yards in each of his 16 previous road appearances against division opponents.
- Cam Ward has recorded 20+ completions in each of the Titans’ last six October games.
- Calvin Ridley has recorded 30+ rushing and receiving yards in each of his 16 previous road appearances against division opponents.
- Michael Carter has recorded 25+ rushing yards in each of his last six appearances against AFC opponents.
- Heading into Week 6, Carnell Tate has the equal-most targets without a receiving touchdown this season (37).
Matchup/League Facts
- Colts – five different players have recorded 60+ receiving yards in a game this season – equal-most in the NFL, heading into Week 6.
- Heading into Week 6, the Colts rank 1st in the NFL in average kickoff return (29.8 yards) this season.
- Heading into Week 6, the Titans rank 32nd in the NFL in points per game (11.6) this season.
- Heading into Week 6, the Titans rank 32nd in the NFL in yards per game (246.4) this season.
Titans vs Colts Prediction
In this Titans vs Colts Prediction, the Colts are coming as -7 home favorites. The Titans have been terrible this season, being one of the three winless teams still left in the NFL, having the worst offense in the league with just 11.6 points per game. On the flip side, the Colts have won two of their last three games and are 3-1 ATS in their last four and almost crack the top-10 of the league in points per game with 24.8. They have also been dominating the Titans in recent years, having won their last six head-to-head meetings and are 6-0 ATS, so I expect them to get the job done in a comfortable fashion today at home. Take the Colts and lay the -7 points in this one.