Seattle (2-1) vs Arizona (2-1)
September 25, 2025 at 08:15 PM EDT
The Line: Betting Odds: Arizona -1 — Over/Under: +43.5
The Seattle Seahawks and Arizona Cardinals meet Thursday in NFL action at State Farm Stadium. Here’s a Seattle Seahawks vs Arizona Cardinals Prediction. This article will include a Seattle Seahawks vs Arizona Cardinals Pick.
The Seattle Seahawks beat the Steelers and Saints, and they play the Buccaneers next. The Seahawks have won 8 of their last 11 games. Sam Darnold is completing 70.3 percent of his passes for 663 yards, 4 touchdowns, and 2 interceptions. Jaxon Smith-Njigba and Cooper Kupp have combined for 459 receiving yards and 1 touchdown, while Toy Horton has 5 receptions.
The Arizona Cardinals beat the Panthers, lost to the 49ers, and play the Titans next. The Arizona Cardinals have split their last 8 games. Kyler Murray is completing 67.4 percent of his passes for 542 yards, 4 touchdowns, and 1 interception. Trey McBride and Marvin Harrison Jr. have combined for 324 receiving yards and 2 touchdowns, while Elijah Higgins has 4 receptions.
The Arizona Cardinals ground game is averaging 111.3 yards per contest, and Trey Benson leads the way with 125 yards on 21 carries. Defensively, Arizona is allowing 17 points and 340.7 yards per game. Mack Wilson Sr. leads the Arizona Cardinals with 28 tackles, Calais Campbell has 2 sacks and Baron Browning has 1 interception.
I’m not sure what to think of the Cardinals, as they looked sharp in their first two games but looked bad in a loss to the banged up 49ers. Then you have to remind yourself the Card’s first two games were against the Saints and Panthers. The Cardinals are also 30th in pass defense, and they’re going up against a Seahawks’ offense that has talent on the outside, and Darnold is picking up where he left off last season. The Cardinals haven’t won a game against the Seahawks since November 2021. So, while I like home teams on Thursday, a short week, but I’m leaning toward the Seahawks in this spot.
Seattle Seahawks Betting Preview
The Seattle Seahawks beat the Steelers and Saints, and they play the Buccaneers next. The Seahawks have won 8 of their last 11 games. Sam Darnold is completing 70.3 percent of his passes for 663 yards, 4 touchdowns, and 2 interceptions. Jaxon Smith-Njigba and Cooper Kupp have combined for 459 receiving yards and 1 touchdown, while Toy Horton has 5 receptions.
The Seattle Seahawks ground game is averaging 96 yards per contest, and Kenneth Walker III leads the way with 163 yards and 3 touchdowns. Defensively, Seattle is allowing 15.7 points and 311.7 yards per game. Ernest Jones IV leads the Seattle Seahawks with 25 tackles, Byron Murphy II has 2.5 sacks and Derion Kendrick has 2 interceptions.
Arizona Cardinals Betting Preview
The Arizona Cardinals beat the Panthers, lost to the 49ers, and play the Titans next. The Arizona Cardinals have split their last 8 games. Kyler Murray is completing 67.4 percent of his passes for 542 yards, 4 touchdowns, and 1 interception. Trey McBride and Marvin Harrison Jr. have combined for 324 receiving yards and 2 touchdowns, while Elijah Higgins has 4 receptions.
The Arizona Cardinals ground game is averaging 111.3 yards per contest, and Trey Benson leads the way with 125 yards on 21 carries. Defensively, Arizona is allowing 17 points and 340.7 yards per game. Mack Wilson Sr. leads the Arizona Cardinals with 28 tackles, Calais Campbell has 2 sacks and Baron Browning has 1 interception.
Seattle Seahawks @ Arizona Cardinals Betting Trends: Week 4
Why the Arizona Cardinals will win
- The home team has won six of the Cardinals’ last seven games.
- The Seahawks have lost five of their last six Thursday games.
- The Seahawks have failed to cover the spread in each of their last four Thursday games played on the West Coast.
- The Cardinals have covered the spread in six of their last seven games following a road loss.
- The favorites have won the first quarter in seven the Seahawks’ last eight Week 4 games.
- The Cardinals have won the first half in six of their last seven home games.
Why the Seattle Seahawks will win
- The Cardinals have lost each of their last eight games against NFC West opponents on a winning streak.
- The Seahawks have won each of their last five games as road underdogs.
- The underdogs have covered the spread in each of the Seahawks’ last six games at State Farm Stadium.
- The Cardinals have failed to cover the spread in four of their last five September games as home favorites against NFC opponents.
- The Cardinals have lost the first half in five of their last six games against NFC West opponents.
- The Seahawks have won the first quarter in three of their last four road games against teams that held a winning record.
Total Points Facts
- Each of the Cardinals’ last seven games as home favorites following a loss have gone OVER the total points line.
- Seven of the Seahawks’ last eight September games against NFC West opponents have gone UNDER the total points line.
- Three of the last four Thursday games at State Farm Stadium have gone OVER the total points line.
Arizona Cardinals Player Prop Facts
- Kyler Murray has recorded 232+ passing yards in eight of the Cardinals’ last nine games following a road loss.
- Kyler Murray has recorded 21+ completions in 13 of his last 14 home appearances against NFC West opponents.
- James Conner has scored a touchdown in seven of his last eight September appearances with his team as a home favorite.
- Zay Jones has recorded 13+ receiving yards in eight of his last nine home appearances against division opponents.
- James Conner has recorded 68+ rushing yards in seven of his last eight appearances following a loss.
- James Conner has recorded 89+ rushing and receiving yards in each of his last four home appearances against NFC West opponents.
- Heading into Week 4, Zaven Collins ranks T2nd in the league for fumbles recovered (1) this season.
Seattle Seahawks Player Prop Facts
- Sam Darnold has recorded 240+ passing yards in seven of his last eight regular season road appearances.
- Cooper Kupp has recorded 44+ receiving yards in nine of his last 10 September road appearances.
- Sam Darnold has recorded 10+ rushing yards in 13 of his last 14 appearances with his team as an underdog against NFC opponents.
- Sam Darnold has recorded 20+ completions in five of his last six regular season road appearances.
- Kenneth Walker III has scored at least one touchdown in each of the Seahawks’ last four games as road underdogs against teams with a winning record.
- Cooper Kupp has recorded 46+ rushing and receiving yards in nine of his last 10 September road appearances.
- Heading into Week 4, Derion Kendrick leads the league for interceptions (2) this season.
Matchup/League Facts
- Heading into Week 4, the Cardinals rank T1st in the NFL in Q3 win percentage (100.0) this season.
- Heading into Week 4, the Cardinals rank 32nd in the NFL in average points scored in fourth quarters this season (3.0).
- Heading into Week 4, the Seahawks are the only team in the NFL to record a Kickoff Return Touchdown and a Punt Return Touchdown this season.
- Heading into Week 4, the Seahawks rank T1st in the NFL in Q1 points per game (9.3) this season.
Seattle Seahawks vs Arizona Cardinals Prediction
I’m not sure what to think of the Cardinals, as they looked sharp in their first two games but looked bad in a loss to the banged up 49ers. Then you have to remind yourself the Card’s first two games were against the Saints and Panthers. The Cardinals are also 30th in pass defense, and they’re going up against a Seahawks’ offense that has talent on the outside, and Darnold is picking up where he left off last season. The Cardinals haven’t won a game against the Seahawks since November 2021. So, while I like home teams on Thursday, a short week, but I’m leaning toward the Seahawks in this spot.