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San Francisco 49ers vs Philadelphia Eagles Prediction 1/11/2026 Today’s NFL Picks

Dec 28, 2025; Orchard Park, New York, USA; Philadelphia Eagles quarterback Jalen Hurts (1) looks to throw a pass in heavy rain against the Buffalo Bills during the second quarter at Highmark Stadium. Mandatory Credit: Mark Konezny-Imagn Images

Dec 28, 2025; Orchard Park, New York, USA; Philadelphia Eagles quarterback Jalen Hurts (1) looks to throw a pass in heavy rain against the Buffalo Bills during the second quarter at Highmark Stadium. Mandatory Credit: Mark Konezny-Imagn Images

MATCHUP San Francisco 49ers Philadelphia Eagles
Team Records 12-5 11-6
Spread +6 -112 -6 -108
Moneyline +220 -270
Total Over 44.5 (-108) Under 44.5 (-112)
Where Lincoln Financial Field, Philadelphia, PA
When Sunday, January 11, 2026
Time 04:30 PM EST
TV FOX

The San Francisco 49ers and the Philadephia Eagles meet in NFL Playoff Wild Card Round action from Levi’s Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco 49ers vs. Philadephia Eagles prediction.

San Francisco 49ers Recap

The San Francisco 49ers come into the playoffs after finishing the year with an overall record of 12-5 on the year. 

49ers Looking To Make Noise In Playoff Return

Mac Jones has thrown for 2,151 yards, 13 touchdowns and 6 interceptions on 69.6% passing while Brock Purdy has thrown for 2,167 yards, 20 touchdowns and 10 interceptions on 69.4% passing. Christian McCaffrey has a team-high 1,202 rushing yards and 10 TDs while also leading the 49ers in receiving with 102 grabs for 924 yards and 7 touchdowns. Ricky Pearsall has 528 receiving yards and 36 receptions while Kendrick Bourne has 551 receiving yards and Jauan Jennings has 643 receiving yards and 9 TDs. George Kittle also has 628 receiving yards and 57 catches along with 7 touchdowns this season. Three more 49ers have 200+ receiving yards as well on the year. On defense, Dee Winters has a team-high 101 total tackles. Bryce Huff and Clelin Ferrell each have a team-high 4 sacks. As a unit, San Francisco’s defense has combined for 20 sacks and 6 interceptions so far this season. 

Philadephia Eagles Recap

The Philadephia Eagles come into the playoffs as the reigning NFC East and Super Bowl champions after finishing the year 11-6 overall.

Eagles Begin Super Bowl Title Defense

Jalen Hurts has thrown for 3,224 yards, 25 touchdowns and 6 interceptions on 64.8% passing while also rushing for 421 yards and 8 touchdowns. Saquon Barkley leads the Eagles with 1,140 rushing yards and 7 touchdowns while DeVonta Smith has 77 grabs for 1,008 yards and 4 TDs. Dallas Goedert has 60 receptions for 591 yards and 11 touchdowns and A.J. Brown has a team-high 78 catches for 1,003 yards and 7 TDs as well this season. On defense, Zack Baun has a team-high 123 total tackles including 64 solo tackles and 3.5 sacks while Jalyx Hunt has a team-high 6.5 sacks. Moro Ojomo has 6 sacks and Jordan Davis has 4.5 sacks while Hunt also has a team-high 3 interceptions. As a unit, the Eagles’ defense as a whole has combined for 42 sacks and 12 interceptions this season.

San Francisco 49ers @ Philadelphia Eagles Betting Trends: Wild Card Round

Why the Philadelphia Eagles will win

Why the San Francisco 49ers will win

Total Points Facts

Philadelphia Eagles Player Prop Facts

San Francisco 49ers Player Prop Facts

Matchup/League Facts

San Francisco 49ers vs. Philadephia Eagles Prediction

I’m looking at the 49ers and the points. I just think between two teams with really solid defenses, it’s the Niners’ offense that’s been far more trustworthy up to this point in the year. The Eagles have been bailed out by their defense a ton this year being outgained in so many of their games to this point and I think that this could be the same kind of deal here. Give me San Francisco and the points.

Chris Ruffolo's Pick: San Francisco +5.5

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