Panthers vs Saints Prediction 11/15/2026 Today’s NFL Picks

Panthers vs Saints Prediction

In this Panthers vs Saints Prediction, the Saints are coming as -2.5 home favorites. Both teams have identical overall records this season and both have been in bad form lately. The Saints are 2-4 in their last 6 games and 1-5 against the spread, while having won only once at home this season. The Panthers have three straight losses and have failed to cover the spread and while they have a better offense than the Saints overall, they average just 17.6 points per game in their last three. They also have a bad history against the Saints, as they are 1-5 in their last 6 meetings and have lost their last three visits in New Orleans. Take the Saints and lay the small number in this one.

New Orleans Saints Preview

The New Orleans Saints have a 3-5 record this season are sitting on the 1st place of the NFC South. They have a 1-4 home record and are 2-1 on the road and are 3-5 against the spread and 5-3 in over/under. They are coming off a 23-22 home win against the Browns and will face the Bears and the Bengals next.

Offensively, the Saints average 23.1 points per game, ranking 15th in the NFL, while defensively, they allow 27 points per game, which is 27th. New Orleans averages 325.8 total yards per game (230.5 passing and 95.3 rushing), while allowing 370.5 total yards per game (133.9 rushing and 236.6 passing). They average 4.9 yards per play, while allowing 5.7 yards per play to opponents. They score on 37.2% of their offensive drives, while averaging 2.09 points per drive. Defensively, they allow opponents to score on 45.6% of drives, while allowing 2.43 points per drive. Offensively, they have turned the ball over 15 times, while defensively, they have forced 9 turnovers, giving them a -6 net turnover margin.

Tyler Shough leads the Saints with 1986 passing yards with 66.2% completed passes and 14 touchdowns. Tyler Shough leads the team in rushing yards with 162, while Chris Olave has 56 receptions for a team-high 734 receiving yards. Defensively, Pete Werner has a team-high 65 total tackles (29 of them solo), while Chase Young leads the team in sacks, with 8.

Injury Report:

• Taliese Fuaga (Questionable, Knee) – Est. return Nov 15

• David Edwards (Questionable, Knee) – Est. return Nov 15

• Kelvin Banks Jr. (Questionable, Ankle) – Est. return Nov 15

• Quincy Riley (Questionable, Knee) – Est. return Nov 15

• CJ Donaldson (Questionable, Shoulder) – Est. return Nov 15

Carolina Panthers Preview

The Carolina Panthers have a 3-5 record this season are sitting on the 1st place of the NFC South. They have a 1-3 home record and are 2-2 on the road and are 3-5 against the spread and 4-4 in over/under. They are coming off a 21-26 home loss against the Broncos and will face the Ravens and the Buccaneers next.

Offensively, the Panthers average 24.9 points per game, ranking 11th in the NFL, while defensively, they allow 27.4 points per game, which is 28th. Carolina averages 362.4 total yards per game (261.1 passing and 101.3 rushing), while allowing 344.9 total yards per game (133.4 rushing and 211.5 passing). They average 5.5 yards per play, while allowing 5.3 yards per play to opponents. They score on 40.4% of their offensive drives, while averaging 2.25 points per drive. Defensively, they allow opponents to score on 41.1% of drives, while allowing 2.34 points per drive. Offensively, they have turned the ball over 12 times, while defensively, they have forced 11 turnovers, giving them a -1 net turnover margin.

Bryce Young leads the Panthers with 2197 passing yards with 60.4% completed passes and 16 touchdowns. Chuba Hubbard leads the team in rushing yards with 619, while Tetairoa McMillan has 46 receptions for a team-high 625 receiving yards. Defensively, Devin Lloyd has a team-high 54 total tackles (32 of them solo), while Princely Umanmielen leads the team in sacks, with 3.

Injury Report:

• Xavier Legette (IR-R, Knee) – Est. return Nov 15

• Jonathon Brooks (IR-R, Groin) – Est. return Nov 15

• Bobby Okereke (Questionable, Foot) – Est. return Nov 15

• Mike Jackson (IR-R, Groin) – Est. return Nov 15

• Jaycee Horn (IR, Quadriceps) – Est. return Nov 15

Carolina Panthers @ New Orleans Saints Betting Trends: Week 10

 

Why the New Orleans Saints will win

• The Saints have won seven of their last eight home games against opponents on a losing streak.
• The Panthers have lost each of their last four road games without Jalen Coker.
• The Saints have covered the spread in seven of their last eight games without Julian Blackmon.
• The Panthers have failed to cover the spread in four of their last five games without Bryce Young.
• The Saints have won the first quarter in three of their last four games after coming off overtime.
• The Saints have won the first half in each of their last four home games following an overtime win.

Why the Carolina Panthers will win

• The Saints have lost each of their last four November games as favorites against NFC South opponents.
• The Panthers have won four of their last five games as underdogs against NFC South opponents.
• The Panthers have covered the spread in seven of their last eight games as underdogs against NFC South opponents.
• The Saints have failed to cover the spread in seven of their last eight November games as favorites.
• The Saints have lost the first quarter in each of their last four games as favorites against NFC opponents.
• The Panthers have won the first half in each of their last four Week 10 games as underdogs.

Total Points Facts

• Each of the Panthers’ last six road games against NFC opponents have gone UNDER the total points line.
• Each of the Saints’ last five games as favorites have gone OVER the total points line.
• Eleven of the last 14 Sunday day games at Caesars Superdome have gone UNDER the total points line.

New Orleans Saints Player Prop Facts

• Audric Estime has scored a touchdown in three of his last four appearances.
• Tyler Shough has recorded 22+ rushing yards in four of the Saints’ last five games against NFC South opponents.
• Tyler Shough has recorded 255+ passing yards in each of the Saints’ last four games as home favorites.
• Juwan Johnson has recorded 26+ receiving yards in seven of the Saints’ last eight games as favorites following a win.
• Tyler Shough has recorded 29+ completions in three of the Saints’ last four Sunday games as home favorites.
• Audric Estime has recorded 77+ rushing and receiving yards in three of his last four appearances.
• Heading into Week 10, Tyler Shough ranks 1st in the league for times blitzed (112) this season.

Carolina Panthers Player Prop Facts

• Tetairoa McMillan has scored the last touchdown in each of the Panthers’ last four November games as underdogs.
• Tetairoa McMillan has scored at least one touchdown in each of the Panthers’ last four November games.
• Bryce Young has recorded 266+ passing yards in each of the Panthers’ last four day road games.
• Bryce Young has recorded 23+ completions in each of the Panthers’ last five games following a loss.
• AJ Dillon has recorded 10+ receiving yards in each of his six previous November road appearances.
• AJ Dillon has recorded 14+ rushing yards in each of his 14 previous appearances in Sunday day games with his team as an underdog.
• AJ Dillon has recorded 28+ rushing and receiving yards in each of his last 13 appearances in Sunday day games with his team as an underdog.
• Heading into Week 10, Jalen Coker ranks T3rd in the NFC for 20+ yard receiving touchdowns (2) this season.

Matchup/League Facts

• Heading into Week 10, the Saints rank 32nd in the NFL in Q1 points per game (1.1) this season.
• Heading into Week 10, the Saints rank 32nd in the NFL in average points scored in first quarters this season (1.1).
• Heading into Week 10, the Panthers have recorded the largest margin of victory in a road game this season (31-points vs Atlanta on September 20, 2026).
• Heading into Week 10, the Panthers have conceded the highest score in a single game this season (59-points vs Chicago).

Nick Lagouretos's Pick: New Orleans Saints -2.5