New York Giants vs New Orleans Saints Prediction 10/5/2025 Today’s NFL Picks

The New York Giants and the New Orleans Saints meet in week 5 NFL action from Caesars Superdome on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a New York Giants vs. New Orleans Saints prediction.

New York Giants Recap

The New York Giants come into this game looking to build on their 21-18 win over the Los Angeles Chargers last time out to sit at 1-3 this season. After this game, the Giants will head home for a game against the Philadelphia Eagles.

Giants Pick Up First W Of Season

Jaxson Dart has thrown for 111 yards and a touchdown on 65% passing. Cam Skattebo also has 181 rushing yards with 2 touchdowns while Malik Nabers leads the Giants with 18 catches for 271 yards and 2 touchdowns but will miss the rest of the season because of injury and Wan’Dale Robinson has 18 grabs for 237 yards and a TD. Darius Slayton also has 135 receiving yards as well this season. On defense, Bobby Okereke has a team-high 38 total tackles including 18 solo tackles while Paulson Adebo has 31 total tackles including a team-high 26 solo tackles. Brian Burns also leads the Giants with 5 sacks as well this season. As a unit, the Giants have combined for 10 sacks and 3 interceptions so far this season.

New Orleans Saints Recap

The New Orleans Saints come into this game looking to come back from a 31-19 loss at the hands of the Buffalo Bills last time out to fall to 0-4 on the year. After this game, the Saints will take on the New England Patriots at home.

Saints Still Searching For First W

Spencer Rattler has thrown for 765 yards, 5 touchdowns and an interception on 67.1% passing while Alvin Kamara has 256 rushing yards and a touchdown to lead the Saints on the ground. Juwan Johnson has a team-high 204 receiving yards with a touchdown on 22 receptions while Chris Olave has a team-high 26 catches for 185 yards and Rashid Shaheed’s added 174 receiving yards and a TD as well. On defense, Demario Davis has a team-high 38 total tackles while Carl Granderson leads New Orleans with 4.5 sacks. As a unit, the Saints have combined for 11 sacks and an interception so far this season.

New York Giants @ New Orleans Saints Betting Trends: Week 5

Why the New Orleans Saints will win

• The Giants have lost each of their last 10 games against NFC opponents.
• The favorites have won each of the Saints’ last 10 games.
• The Giants have failed to cover the spread in each of their last four road games following a win.
• The Saints have covered the spread in each of their last four Week 5 games against NFC opponents.
• The Giants have lost the first half in each of their last seven road games following a win.
• The Giants have lost the first quarter in each of their last six games following a win.

Why the New York Giants will win

• The Saints have lost each of their last eight games.
• The Giants have won each of their last two Week 5 games as underdogs against NFC opponents.
• The Saints have failed to cover the spread in seven of their last eight home games following a road loss.
• The road team has covered the spread in five of the Saints’ last six games.
• The Saints have lost the first half in seven of their last eight games.
• The Saints have lost the first quarter in each of their last three Week 5 games as home favorites.

Total Points Facts

• Each of the Giants’ last eight games against NFC South opponents have gone UNDER the total points line.
• Each of the Saints’ last six Week 5 games against NFC opponents have gone OVER the total points line.

New Orleans Saints Player Prop Facts

• Brandin Cooks has scored a touchdown in seven of his eight appearances with his team as a home favorite against teams with a losing record.
• Alvin Kamara has recorded 33+ receiving yards in each of the Saints’ last seven October games as favorites.
• Spencer Rattler has recorded 207+ passing yards in each of the Saints’ last four games against NFC opponents.
• Alvin Kamara has recorded 66+ rushing yards in each of the Saints’ last five games as home favorites against NFC East opponents.
• Alvin Kamara has recorded 84+ rushing and receiving yards in each of his last 12 October appearances with the Saints as favorites.
• Spencer Rattler has recorded 25+ completions in each of the Saints’ last four games against NFC opponents.
• Heading into Week 5, Alvin Kamara ranks 1st in the league amongst qualified players for broken tackle percentage (65.0%) this season.

New York Giants Player Prop Facts

• Wan’Dale Robinson has scored a touchdown in three of the Giants’ last four road games against teams on a losing streak.
• Devin Singletary has recorded 18+ rushing yards in each of his last 12 appearances following a win.
• Devin Singletary has recorded 38+ rushing and receiving yards in 11 of his last 12 appearances following a win.
• Darius Slayton has recorded 22+ receiving yards in 11 of his 12 previous October appearances with the Giants as underdogs against NFC opponents.
• Heading into Week 5, Brian Burns ranks T1st in the NFL in sacks (5.0) this season.

Matchup/League Facts

• Heading into Week 5, the Saints rank 32nd in the NFL in 4th down percentage (25.0%) this season.
• Heading into Week 5, the Saints rank T1st in the NFL in 4th down percentage against (0.0%) this season.
• Giants – two different players have recorded 100+ receiving yards in a game this season – equal-most in the NFL, heading into Week 5.
• Heading into Week 5, the Giants rank 32nd in the NFL in red zone percentage (26.7%) this season.

New York Giants vs. New Orleans Saints Prediction

I’m on the Giants and the points in this one. I get the case to be made for the Saints laying points at home and New Orleans has been surprisingly competitive so far this season. However, I still think that the Giants were more impressive with their win over the Chargers last week, and I shudder to think of what could happen here for Spencer Rattler against this Giants pass rush. I think that the Giants get a solid win on the road here so give me New York and the points to be safe.